Human biomonitoring to evaluate exposure to toxic and essential trace elements during pregnancy. Part A. concentrations in maternal blood, urine and cord blood

Environmental Research
Beatrice BoccaMarta Schuhmacher

Abstract

Exposures to toxic elements or deficiencies of essential elements during pregnancy may be associated to various birth complications or even diseases in early life. The aim of this paper was to assess the concentrations of selected toxic (As, Cd, Cr, Hg, Ni, Pb) and essential trace elements (Co, Cu, Mn, Se and Zn) in blood and urine samples of delivering women at different periods of gestation and cord blood, as well as to evaluate the placental permeability for these elements. A total of 53 women participating in the HEALS-EXHES study were enrolled. In particular, 48 blood samples from 1st trimester of pregnancy, 40 blood samples at delivery, and 31 cord blood at delivery were collected. Moreover, mothers' urine were sampled at the 1st (53 samples), 2nd (53 samples) and 3rd trimester (49 samples) of pregnancy. Results showed that Hg and Mn levels in cord blood were about 2.0 times higher than in maternal blood, suggesting that these elements may be transferred from mother to fetus. The cord blood levels of As and Pb were lower (ca. the 65%) than those in maternal blood, showing that the placenta modulates the rate of transfer for these elements. Essential elements as Cu and Zn showed significantly lower levels in cord than in m...Continue Reading

Citations

Oct 23, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Giancarlo PesceIsabella Annesi-Maesano
Dec 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Patricia Miranda FariasKarine de Cássia Freitas
Jan 15, 2021·The Science of the Total Environment·Mohammad NaderiRaymond W M Kwong
Mar 2, 2021·Environmental Research·María Ángeles MartínezMartí Nadal
Jan 4, 2021·Endocrine Reviews·Vasantha PadmanabhanMuraly Puttabyatappa
Aug 7, 2021·Environment International·Gwen TindulaMaitreyi Mazumdar
Aug 3, 2021·The Journal of Toxicological Sciences·Qing HanGaochun Zhu

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