Human Bocavirus-infection (HBoV): an important cause of severe viral obstructive bronchitis in children

Klinische Pädiatrie
M HengstMichael Kleines

Abstract

Apart from established pathogens of lower respiratory tract infections, such as respiratory syncytial virus (RSV), an increasing number of additional agents has been identified in recent years. In 2005 the human bocavirus (hBoV) has been isolated from respiratory tract samples and has been reported worldwide with frequencies ranging from 1.5 to 18.3% in respiratory samples from children with airway infections. We investigated 173 specimens of a total number of 162 children who were inpatients with severe respiratory tract infections most of whom required oxygen therapy. We analyzed respiratory tract samples (83% nasopharyngeal washes, 15% tracheal secretions, 2% bronchoalveolar lavages) for adenoviruses, influenza A und B viruses, parainfluenzaviruses types 1 to 3 and RSV using antigen-specific immunofluorescence assays. Additionally we tested human metapneumovirus (hMPV) and hBoV using a PCR assay. 35.8% specimens were negative in all assays, 54.3% were positive for RSV and 9.8% were positive for adeno-, influenza-, parainfluenzaviruses or hMPV. HBoV could be detected in 17 specimens (9.8%), defining HBoV to be the second most frequent pathogen. Nine of these patients showed a coinfection with RSV, one with parainfluenza virus...Continue Reading

Citations

Jun 3, 2015·Nutrients·Claire L Greiller, Adrian R Martineau
Mar 22, 2016·Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·S RudolfM König
Jun 1, 2009·Viruses·Jessica LüsebrinkOliver Schildgen
May 29, 2021·Applied and Environmental Microbiology·Kattareeya KumthipNiwat Maneekarn

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