PMID: 6975588Dec 1, 1981Paper

Human bone marrow biochemical function and megaloblastic hematopoiesis after nitrous oxide anesthesia

Anesthesiology
H O'SullivanD G Weir

Abstract

Prolonged exposure to nitrous oxide (N2O) inhibits bone marrow function. The duration of exposure to nitrous oxide necessary to induce these changes and their permanence is unknown. The possible prophylactic effect of prior treatment with folinic acid has not been examined previously. Bone marrow function in patients receiving nitrous oxide was assessed by the deoxyuridine (dU) suppression test. Morphologic changes in the bone marrow were also studied. One group was exposed for under 6 h, the next for between 12 and 24 h and a control group who received nonitrous oxide. The control group and the short exposure group showed no abnormality of bone marrow function. The long exposure group had abnormal dU supression tests and a megaloblastic hematopoiesis. The changes observed in this group resolved 12 h after discontinuance of the anesthetic. The changes observed could be prevented by the preoperative administration of folinic acid. The absence of either morphologic or dU suppression test abnormalities following N2O anesthesia for periods of less than 6 h confirms the safety of this anesthetic for the majority of operations for which it is used. It has been confirmed that prolonged exposure to the gas causes impaired marrow functi...Continue Reading

Citations

Jan 1, 1990·Seminars in Surgical Oncology·D D Koblin
Apr 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J S Mallon, G Edelist
Jan 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·P G Duncan, M M Cohen
Jan 1, 1984·Canadian Anaesthetists' Society Journal·T M Bird, L Strunin
Mar 26, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K HaraY Kosaka
Jun 5, 1998·Anaesthesia·A D Shaw, M Morgan
Oct 29, 2013·Journal of Anesthesia·Hanjo KoRichard D Urman
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·J Metz
Jan 1, 1985·Critical Reviews in Oncology/hematology·Y KanoF Takaku
Dec 16, 2006·Journal of Cosmetic Dermatology·Garrett Bird, Clifford Albert
Feb 1, 1984·Acta Anaesthesiologica Scandinavica·M SaloJ Nikoskelainen
Nov 1, 1994·The Journal of Pediatrics·Q A FisherM D Wilson
Dec 1, 1992·The Journal of the American Dental Association·R J Henry
May 20, 2003·Best Practice & Research. Clinical Anaesthesiology·Jörg Weimann
Oct 1, 1995·Anesthesiology·A HadzicD M Thys
Sep 25, 2008·Anesthesiology·Robert D SandersMervyn Maze
Nov 6, 2018·BMJ : British Medical Journal·Anita AcharyaAlastair Noyce
Feb 7, 2015·Anesthesia and Analgesia·Andreas DumaPeter Nagele
Jun 18, 2011·Anesthesia and Analgesia·Peter NageleEvan D Kharasch
Jul 17, 1998·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·D KaracostasI Milonas
Sep 1, 1986·Medical Toxicology·J B Brodsky, E N Cohen
Nov 1, 1984·Anaesthesia and Intensive Care·J S Willoughby
Apr 10, 2013·The American Journal of Case Reports·Evan T TrivetteBrandy R Jacobs
Sep 27, 2000·Anesthesia and Analgesia·S KathirvelP Sujatha
Feb 17, 2021·British Journal of Clinical Pharmacology·Darmiga Thayabaran, Daniel Burrage
Sep 1, 1988·Blood Reviews·S N Wickramasinghe, J H Matthews
Sep 1, 1995·Baillière's Clinical Haematology·D G Weir, J M Scott

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