Human brain natriuretic peptide reduces blood pressure in normotensive and acute norepinephrine-induced hypertensive rabbits

American Journal of Hypertension
L E ClemensA A Protter

Abstract

Human brain natriuretic peptide (hBNP) is a cardiac-derived peptide hormone with potent hemodynamic and renal effects in dogs, monkeys, and humans, but not in rats. At present there is no small animal model to study the actions of hBNP. These studies describe the effects of hBNP in New Zealand White rabbits in normotensive and acute norepinephrine-induced hypertensive states. Intravenous administration of hBNP (1, 3, 10, and 30 microg/kg) to anesthetized rabbits resulted in a dose-dependent diuresis and natriuresis and a decrease in systolic blood pressure. Bolus administration of hBNP resulted in a time- and dose-dependent accumulation of plasma cyclic GMP, consistent with activation of a particulate guanylyl cyclase receptor. The hemodynamic actions of hBNP suggest clinical utility for the management of acute hypertension associated with numerous surgical procedures, a condition linked to catecholamine activation. In rabbits with norepinephrine-induced acute hypertension, bolus and continuous infusion of hBNP markedly reduced blood pressure. These studies demonstrate that the rabbit is a useful species to study the hemodynamic and renal effects of hBNP and that this peptide may have therapeutic utility for the acute reduction...Continue Reading

Citations

Jan 29, 2005·Paediatric Anaesthesia·Todd SmithJoseph D Tobias
Jul 5, 2005·Expert Opinion on Investigational Drugs·R E Hobbs, R M Mills
Apr 27, 2001·Expert Opinion on Investigational Drugs·R E HobbsJ B Young
Jun 5, 2019·Journal of Cardiovascular Pharmacology and Therapeutics·Hongyan ZhaoWeimin Li

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