journal cover

Human breast tumor-infiltrating CD8+ T cells retain polyfunctionality despite PD-1 expression

Nature Communications

Oct 18, 2018

Colt A EgelstonPeter P Lee

Abstract

Functional CD8+ T cells in human tumors play a clear role in clinical prognosis and response to immunotherapeutic interventions. PD-1 expression in T cells involved in chronic infections and tumors such as melanoma often correlates with a state of T-cell exhaustion. Here we interrogate ...read more

Mentioned in this Paper

PTK6 gene
T-Lymphocyte
Tumor Necrosis Factor-alpha
Suppressor T-Lymphocytes, CD8-Positive
Neoplasms
Cell Degranulation
CD8-Positive T-Lymphocytes
Cell Differentiation Process
Melanoma vaccine
Infiltration
23
11
64

Similar Papers Found In These Feeds

Downstream Antiviral T Cell

Non-Small Cell Lung Cancer Recurrence

General Biology Journal eTOCs

Discover the latest general biology research in this collection of the top biology journals.

Immune Therapies In Cancer

Immunotherapy in cancer is used to help the immune system fight against invading cancer cells. It is used to slow the progression of the disease and prevent metastasis while enhancing the immune response. There are different types, including monoclonal antibodies and checkpoint inhibitors. Here is the latest research on immune therapies in cancer.

T cell Differentiation

Differentiation of naive T cells into effector cells ensures optimal protection against pathogens and the development of immunological memory. Here is the latest research.

Skin Cutaneous Melanoma

Cutaneous melanoma is a cancer of the pigment-producing cells known as melanocytes. While it has a 98 percent five-year survival rate when caught early, thousands of deaths are attributed to this cancer each year. Here is the latest research.

Cross-Priming

Cross-priming is the process whereby professional APC, mainly dendritic cells, prime t-cells by presenting antigens processed from proteins of other cells such as tumor cells or virus-infected cells. Discover the latest research on cross-priming here.

© 2020 Meta ULC. All rights reserved

Human breast tumor-infiltrating CD8+ T cells retain polyfunctionality despite PD-1 expression

Nature Communications

Oct 18, 2018

Colt A EgelstonPeter P Lee

PMID: 30327458

DOI: 10.1038/s41467-018-06653-9

Abstract

Functional CD8+ T cells in human tumors play a clear role in clinical prognosis and response to immunotherapeutic interventions. PD-1 expression in T cells involved in chronic infections and tumors such as melanoma often correlates with a state of T-cell exhaustion. Here we interrogate ...read more

Mentioned in this Paper

PTK6 gene
T-Lymphocyte
Tumor Necrosis Factor-alpha
Suppressor T-Lymphocytes, CD8-Positive
Neoplasms
Cell Degranulation
CD8-Positive T-Lymphocytes
Cell Differentiation Process
Melanoma vaccine
Infiltration
23
11
64

Related Papers

/papers/human-breast-tumor-infiltrating-cd8-t-cells/30327458