PMID: 8995701Feb 1, 1997Paper

Human carcinoembryonic antigen and biliary glycoprotein can serve as mouse hepatitis virus receptors

Journal of Virology
D S ChenM M Lai

Abstract

Receptors for murine coronavirus mouse hepatitis virus (MHV) are members of the murine carcinoembryonic antigen (CEA) gene family. Since MHV can also infect primates and cause central nervous system lesions (G. F. Cabirac et al., Microb. Pathog. 16:349-357, 1994; R. S. Murray et al., Virology 188:274-284, 1992), we examined whether human CEA-related molecules can be used by MHV as potential receptors. Transfection of plasmids expressing human carcinoembryonic antigen (hCEA) and human biliary glycoprotein into COS-7 cells, which lack a functional MHV receptor, conferred susceptibility to two MHV strains, A59 and MHV-2. Domain exchange experiments between human and murine CEA-related molecules identified the immunoglobulin-like loop I of hCEA as the region conferring the virus-binding specificity. This finding expands the potential MHV receptors to primate species.

References

May 1, 1992·Annals of Neurology·R S MurrayG F Cabirac
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·F RudertW Zimmermann
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P GunningL Kedes
Jan 1, 1974·Archiv für die gesamte Virusforschung·N HiranoM Matumoto
May 1, 1994·Microbial Pathogenesis·G F CabiracR S Murray
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·G S DvekslerK V Holmes
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·D S ChenM M Lai

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Citations

Dec 13, 2005·Microbiology and Molecular Biology Reviews : MMBR·Susan R Weiss, Sonia Navas-Martin
Jul 24, 2010·Interdisciplinary Perspectives on Infectious Diseases·Jayasri Das Sarma
Aug 28, 2013·Journal of Neurovirology·Jayasri Das Sarma
Apr 22, 2010·BMC Microbiology·Maike VogesChristof R Hauck

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