Human Cardiac-Mesenchymal Stem Cell-Like Cells, a Novel Cell Population with Therapeutic Potential.

Stem Cells and Development
Rachel OldershawAnnette Meeson

Abstract

Cardiac stem/progenitors are being used in the clinic to treat patients with a range of cardiac pathologies. However, improvements in heart function following treatment have been reported to be variable, with some showing no response. This discrepancy in response remains unresolved. Mesenchymal stem cells (MSCs) have been highlighted as a regenerative tool as these cells display both immunomodulatory and proregenerative activities. The purpose of this study was to derive a cardiac MSC population to provide an alternative/support to current therapies. We derived human cardiac-mesenchymal stem cell-like cells (CMSCLC), so named as they share some MSC characteristics. However, CMSCLC lack the MSC trilineage differentiation capacity, being capable of only rare adipogenic differentiation and demonstrating low/no osteogenic or chondrogenic potential, a phenotype that may have advantages following transplantation. Furthermore, CMSCLC expressed low levels of p16, high levels of MHCI, and low levels of MHCII. A lack of senescent cells would also be advantageous for cells to be used therapeutically, as would the ability to modulate the immune response. Crucially, CMSCLC display a transcriptional profile that includes genes associated wit...Continue Reading

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Citations

Sep 27, 2020·Cardiovascular Drugs and Therapy·Emily DookunGavin D Richardson
Jul 9, 2021·Mechanisms of Ageing and Development·W Andrew OwensGavin D Richardson

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Methods Mentioned

BETA
coronary artery bypass
flow cytometry
FACS
confocal microscopy
biopsy
PCR

Software Mentioned

FACS DiVa
SINGuLAR Analysis Toolset
R
scran R package
Fluidigm
Fluidigm Real - time Analysis
NIS Elements AR
Excel
SPSS

Related Concepts

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