PMID: 9438742Jan 23, 1998Paper

Human cardiovascular and metabolic response to acute, severe isovolemic anemia

JAMA : the Journal of the American Medical Association
R B WeiskopfM A Moore

Abstract

Although concern over the risks of red blood cell transfusion has resulted in several practice guidelines for transfusion, lack of data regarding the physiological effects of anemia in humans has caused uncertainty regarding the blood hemoglobin (Hb) concentration requiring treatment. To test the hypothesis that acute isovolemic reduction of blood Hb concentration to 50 g/L in healthy resting humans would produce inadequate cardiovascular compensation and result in tissue hypoxia secondary to inadequate oxygen transport. Before and after interventional study. Academic tertiary care medical center. Conscious healthy patients (n =11) prior to anesthesia and surgery and volunteers not undergoing surgery (n=21). Aliquots of blood (450-900 mL) were removed to reduce blood Hb concentration from 131 (2) g/L to 50 (1) g/L [mean (SE)]. Isovolemia was maintained with 5% human albumin and/or autologous plasma. Cardiovascular parameters, arterial and mixed venous oxygen content, oxyhemoglobin saturation, and arterial blood lactate were measured before and after removal of each aliquot of blood. Electrocardiogram and, in a subset, Holter monitor were monitored continuously. "Critical" oxygen delivery (TO2) as assessed by oxygen consumption ...Continue Reading

Citations

Sep 29, 2005·Hematology·Jeffrey L Carson, Richard C Reynolds
Aug 28, 2003·Southern Medical Journal·Marian Petrides
Dec 19, 2013·Current Treatment Options in Cardiovascular Medicine·Hanna K Gaggin, G William Dec
Feb 11, 2014·Extreme Physiology & Medicine·Ronan Astin, Zudin Puthucheary
Feb 9, 2012·Current Treatment Options in Neurology·Andreas H Kramer, Peter Le Roux
Dec 6, 2014·Journal of Pediatric Surgery·Casey J AllenJuan E Sola
Sep 11, 2014·Der Anaesthesist·M RoesslerM Bauer
Apr 18, 2013·Best Practice & Research. Clinical Anaesthesiology·Gregory M T HareAryeh Shander
Sep 7, 2002·Annals of the Royal College of Surgeons of England·S SharmaJ P Ivory
Feb 24, 2000·Archives of Disease in Childhood. Fetal and Neonatal Edition·P PladysP Bétrémieux
Mar 18, 2004·Critical Care : the Official Journal of the Critical Care Forum·Jan Bakker, Alex Pinto de Lima
Jun 16, 2004·Critical Care : the Official Journal of the Critical Care Forum·Samir M Fakhry, Paola Fata
Jun 16, 2004·Critical Care : the Official Journal of the Critical Care Forum·John C Marshall
Oct 8, 2004·Critical Care : the Official Journal of the Critical Care Forum·Guillermo GutierrezMarian E Wulf-Gutierrez
Aug 13, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Ryan Zarychanski, Donald S Houston
Jun 13, 2009·Critical Care : the Official Journal of the Critical Care Forum·Andreas H Kramer, David A Zygun
Dec 17, 2009·British Journal of Anaesthesia·S Roth
Oct 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Albert K Y TsuiGregory M T Hare
Dec 9, 2004·Dimensions of Critical Care Nursing : DCCN·Barbara L Maglish Ehrman, Holly A Moore
Sep 6, 2013·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·John C Stover, Bob W Broomer
Jan 15, 2000·Journal of Neurosurgical Anesthesiology·P HansM Lamy
Jun 1, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Albert K Y TsuiGregory M T Hare
Apr 13, 2011·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Gregory M T HareKaterina Pavenski
Jan 25, 2012·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Gregory M T HareC David Mazer
Jan 29, 2013·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Gregory M T HareC David Mazer
Feb 3, 2005·Surgical Infections·Greg J Beilman
Jun 1, 2005·Surgical Infections·John C Marshall
May 14, 2009·Clinical Medicine : Journal of the Royal College of Physicians of London·Luke S Howard
Jul 25, 2007·Annals of Cardiac Anaesthesia·Bharathi H Scott
Apr 12, 2005·Bone Marrow Transplantation·T ParkkaliT Ruutu
Dec 23, 2004·Der Anaesthesist·C MadjdpourD R Spahn
Jan 1, 2010·Acta chirurgica Iugoslavica·Bojan JovanovićVladimir R Djukić
Dec 2, 2000·International Anesthesiology Clinics·M H Wall, R C Prielipp
Sep 19, 2002·American Journal of Therapeutics·Heather A Hume, Pierre Limoges
Oct 3, 2006·Current Opinion in Anaesthesiology·L J Caruso, A Gabrielli
Jan 11, 2007·Current Opinion in Anaesthesiology·Alexander Kulier
Jan 16, 2008·Current Opinion in Anaesthesiology·Robert Tircoveanu, Philippe Van der Linden
Sep 12, 2008·Current Opinion in Anaesthesiology·Tim FrenzelMartin Westphal
May 1, 2001·British Journal of Haematology·M F MurphyUNKNOWN British Committee for Standards in Haematology, Blood Transfusion Task Force
May 11, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·George K IstaphanousAryeh Shander
Jun 8, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Robert I Parker
Apr 19, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Cornelius T Tyrrell, Scot T Bateman
Oct 6, 2011·Annals of Intensive Care·Christophe Lelubre, Jean-Louis Vincent
Sep 28, 2005·Obstetrical & Gynecological Survey·A J G JansenJ J Duvekot
Feb 22, 2011·Heart Failure Reviews·Alberto PalazzuoliRanuccio Nuti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.