Human Carotid Plaques With High Levels of Interleukin-16 Are Associated With Reduced Risk for Cardiovascular Events

Stroke; a Journal of Cerebral Circulation
Caitríona GrönbergHarry Björkbacka

Abstract

Interleukin-16 (IL-16) functions as a regulator of T-cell growth and acts as an inducer of cell migration. The aim of this study was to determine whether IL-16 measured in human carotid plaques was associated with symptoms (eg, stroke, transient ischemic attack, or amaurosis fugax), markers of plaque stability, and postoperative cardiovascular events. Plaques obtained from patients who had ≥1 cerebrovascular ischemic events within 1 month before endarterectomy (n=111) were compared with plaques from patients without symptoms (n=95). Neutral lipids, smooth muscle cell, and macrophage contents were evaluated histologically, and collagen, elastin, and caspase-3 activity were measured biochemically. IL-16, matrix metalloproteinases, and tissue inhibitors of metalloproteinases were measured in plaque homogenates using a multiplex immunoassay. IL-16, CD3, CD4, and FoxP3 mRNA expressions in carotid plaques were analyzed with quantitative real-time polymerase chain reaction. Carotid plaques from asymptomatic patients had higher levels of IL-16 mRNA. High plaque IL-16 protein levels (above median) were associated with reduced incidence of postoperative cardiovascular events during a mean follow-up of 21 months (hazard ratio, 0.47; 95% c...Continue Reading

References

Aug 1, 1997·American Journal of Respiratory Cell and Molecular Biology·S LabergeQ Hamid
Feb 6, 1998·The International Journal of Biochemistry & Cell Biology·D M CenterW W Cruikshank
Mar 8, 2003·Stroke; a Journal of Cerebral Circulation·Isabel GonçalvesMikko P S Ares
Mar 12, 2003·Chest·Frederic F LittleWilliam W Cruikshank
Jun 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andreas ElssnerMark D Wewers
Jan 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Chiara BuonoAndrew H Lichtman
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
Feb 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shilpa RahangdaleWilliam W Cruikshank
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Caroline McFaddenWilliam Cruikshank
Oct 28, 2008·Burns : Journal of the International Society for Burn Injuries·Yoshitaka MatsumotoNoriyuki Sato
May 20, 2011·Nature·Peter LibbyGöran K Hansson
May 20, 2011·Nature·Björn SchwanhäusserMatthias Selbach
Jan 10, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Olivier HerbinZiad Mallat
Nov 30, 2013·Mediators of Inflammation·Xiao-li LiuYa-guo Li

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