Human cathelicidin peptide LL37 binds telomeric G-quadruplex

Molecular BioSystems
Jagannath JanaSubhrangsu Chatterjee


Stabilization of G-quadruplex inhibits the activity of the enzyme telomerase in cancer cells. We found LL37, a host defense human cathelicidin antimicrobial peptide, to be a potent binder of G-quadruplex structures.


May 28, 2003·Biochemistry·Katherine A Henzler WildmanAyyalusamy Ramamoorthy
Sep 10, 2003·Journal of Leukocyte Biology·Margherita Zanetti
Jun 30, 2004·Biochemistry·Katherine A Henzler-WildmanAyyalusamy Ramamoorthy
Dec 13, 2005·American Journal of Respiratory Cell and Molecular Biology·Y Elaine LauDonald J Davidson
Apr 28, 2006·Antimicrobial Agents and Chemotherapy·Oscar CirioniGiorgio Scalise
May 24, 2006·Biochimica Et Biophysica Acta·Ulrich H N DürrAyyalusamy Ramamoorthy
Jan 12, 2007·The European Respiratory Journal·Robert BuckiP A Janmey
Oct 31, 2007·Methods : a Companion to Methods in Enzymology·Sattanathan ParamasivanPhilip H Bolton
May 10, 2011·Journal of the American Chemical Society·Brahim Heddi, Anh Tuân Phan


Sep 24, 2015·Archivum Immunologiae Et Therapiae Experimentalis·Ewelina PiktelRobert Bucki
Jun 5, 2016·Bioinformatics·Shravan SukumarJulie C Mitchell
Apr 17, 2015·Organic & Biomolecular Chemistry·Prachi AgarwalaSouvik Maiti
Jun 14, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marco FranceschinArmandodoriano Bianco
Jan 11, 2018·ChemistryOpen·Meghomukta MukherjeeSubhrangsu Chatterjee

Related Concepts

ALL-38 peptide
Circular Dichroism, Vibrational
Plasma Protein Binding Capacity
Amphipathic Cationic Antimicrobial Peptides
Tumor Cells, Malignant
Cathelicidin antimicrobial peptide
CAMP gene

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, as well as fevers and skin rashes. Here is the latest research on this disease.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.


Trichotillomania is an impulse control disorder characterized by the recurrent pulling of one's hair resulting in noticeable hair loss. Here are the latest discoveries in this field.

DDX3X Syndrome

DDX3X syndrome is caused by a spontaneous mutation at conception that primarily affects females due to its location on the X-chromosome. DDX3X syndrome has been linked to intellectual disabilities, seizures, autism, low muscle tone, brain abnormalities, and slower physical developments. Here is the latest research.