Human CD14 mediates recognition and phagocytosis of apoptotic cells

Nature
A DevittC D Gregory

Abstract

Cells undergoing programmed cell death (apoptosis) are cleared rapidly in vivo by phagocytes without inducing inflammation. Here we show that the glycosylphosphatidylinositol-linked plasma-membrane glycoprotein CD14 on the surface of human macrophages is important for the recognition and clearance of apoptotic cells. CD14 can also act as a receptor that binds bacterial lipopolysaccharide (LPS), triggering inflammatory responses. Overstimulation of CD14 by LPS can cause the often fatal toxic-shock syndrome. Here we show that apoptotic cells interact with CD14, triggering phagocytosis of the apoptotic cells. This interaction depends on a region of CD14 that is identical to, or at least closely associated with, a region known to bind LPS. However, apoptotic cells, unlike LPS, do not provoke the release of pro-inflammatory cytokines from macrophages. These results indicate that clearance of apoptotic cells is mediated by a receptor whose interactions with 'non-self' components (LPS) and 'self' components (apoptotic cells) produce distinct macrophage responses.

References

Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·V UgoliniJ D Capra
Mar 10, 1995·The Journal of Biological Chemistry·T S JuanH S Lichenstein
Sep 1, 1994·Immunity·J PuginR J Ulevitch
Jan 1, 1995·Annual Review of Immunology·R J Ulevitch, P S Tobias
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·R L DeludeD T Golenbock
Jan 1, 1993·European Journal of Immunology·T EspevikA Sundan
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E FerreroS M Goyert
Aug 26, 1993·Nature·J OgasawaraS Nagata
Mar 1, 1993·Immunology Today·J SavillC Haslett
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·N PlattS Gordon
May 1, 1996·Immunology Today·H R Petty, R F Todd
Jan 15, 1997·The Journal of Clinical Investigation·B YuS D Wright
May 1, 1997·Molecular Biology of the Cell·D PradhanR A Schlegel
Dec 6, 1997·Nature·R E VollI Girkontaite

❮ Previous
Next ❯

Citations

Dec 25, 2002·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Hubertus P A JersmannIan Dransfield
Dec 8, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yoshihiro KomoharaMotohiro Takeya
Jul 12, 2002·Microscopy Research and Technique·Meir DjaldettiHanna Bessler
Jul 26, 2002·International Journal of Hematology·F Jon GeskeValerie A Fadok
Aug 3, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Yi LiWestley H Reeves
Jan 6, 2005·Springer Seminars in Immunopathology·Eric C B MilnerIñaki Sanz
Oct 10, 2006·Modern Rheumatology·Gerhard E GrossmayerMartin Herrmann
Sep 1, 2005·Apoptosis : an International Journal on Programmed Cell Death·F WinauU E Schaible
Mar 26, 2010·Apoptosis : an International Journal on Programmed Cell Death·Luciana Dini
Apr 14, 2007·Journal of Mammary Gland Biology and Neoplasia·Torsten SteinBarry A Gusterson
May 9, 2009·Journal of Mammary Gland Biology and Neoplasia·Sara PensaValeria Poli
Apr 22, 2010·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Liang ShiYirong Li
Dec 11, 2008·Immunologic Research·Adam D Kennedy, Frank R DeLeo
Apr 23, 2003·Archives of Biochemistry and Biophysics·Grigory G BorisenkoValerian E Kagan
Oct 17, 2001·Developmental and Comparative Immunology·B G Magor, K E Magor
Sep 5, 1998·Trends in Cell Biology·N PlattS Gordon
Nov 5, 1999·Nature Medicine·S GallucciP Matzinger
May 3, 2008·Cell Death and Differentiation·R B Birge, D S Ucker
Dec 20, 2002·Nature·Jonathan Cohen
Nov 27, 2007·Nature Reviews. Immunology·Kodi S Ravichandran, Ulrike Lorenz
Jul 6, 2000·British Journal of Pharmacology·Z Mallat, A Tedgui
Apr 18, 2003·Cell Death and Differentiation·A DevittC D Gregory
Apr 18, 2003·Cell Death and Differentiation·C TurnerC D Gregory
Oct 27, 2007·Cell Death and Differentiation·S-Y ParkI-S Kim
Nov 9, 2000·Anaesthesia·P C Kam, N I Ferch
Mar 23, 1999·British Journal of Haematology·A AntonelliM Magnani
Jun 10, 2000·British Journal of Haematology·K M GilesI Dransfield
Jan 29, 2000·European Journal of Clinical Investigation·P Antal-Szalmás
Mar 29, 2000·Scandinavian Journal of Immunology·E SunW Gao
Apr 4, 2001·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M YamamotoM Monden
Dec 22, 1998·The Journal of Experimental Medicine·D MevorachK B Elkon
Aug 10, 2000·The Journal of Experimental Medicine·P R TaylorM J Walport
Mar 18, 2004·Antioxidants & Redox Signaling·Alexandra KadlNorbert Leitinger
Jan 10, 2004·Antioxidants & Redox Signaling·Klas Pekkari, Arne Holmgren
Sep 17, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Rebecca A Sosa, Thomas G Forsthuber
Mar 12, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Edith LubosDiane E Handy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis