Human CD43+ B cells are closely related not only to memory B cells phenotypically but also to plasmablasts developmentally in healthy individuals

International Immunology
Masanori InuiToshiyuki Takai

Abstract

CD20(+)CD27(+)CD43(+) B (CD43(+) B) cells have been newly defined among PBMCs and proposed to be human B1 cells. However, it is controversial as to whether they are orthologs of murine B1 cells and how they are related to other B-cell populations, particularly CD20(+)CD27(+)CD43(-) memory B cells and CD20(low)CD27(high)CD43(high) plasmablasts. Our objective is to identify phenotypically the position of CD43(+) B cells among peripheral B-lineage cell compartments in healthy donors, with reference to B-cell subsets from patients with systemic lupus erythematosus (SLE). We found that CD43(+) B cells among PBMCs from healthy subjects were indistinguishable phenotypically from memory B cells in terms of surface markers, and spontaneous in vitro Ig and IL-10 secretion capability, but quite different from plasmablasts. However, a moderate correlation was found in the frequency of CD43(+) B cells with that of plasmablasts in healthy donors but not in SLE patients. An in vitro differentiation experiment indicated that CD43(+) B cells give rise to plasmablasts more efficiently than do memory B cells, suggesting that they are more closely related to plasmablasts developmentally than are memory B cells, which is also supported by quantitat...Continue Reading

References

Feb 1, 1997·Current Biology : CB·L NitschkeM C Lamers
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·H KubagawaM D Cooper
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M OdendahlT Dörner
Jan 6, 2005·Springer Seminars in Immunopathology·Nicole BaumgarthLeonore A Herzenberg
Feb 12, 2005·Advances in Immunology·Michael C Carroll, V Michael Holers
Oct 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Mitsunori ShiroishiKatsumi Maenaka
Sep 25, 2007·Journal of Autoimmunity·Stratis AvrameasPeggy Lymberi
Dec 8, 2007·Nature Reviews. Immunology·Falk Nimmerjahn, Jeffrey V Ravetch
Sep 6, 2008·Advances in Immunology·Stephen M JacksonJ Donald Capra
Nov 8, 2008·Science·Jasvinder K AtwalMarc Tessier-Lavigne
Jul 15, 2009·Immunological Reviews·Lars Nitschke
Mar 5, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julia JellusovaLars Nitschke
Jul 6, 2010·Journal of Immunological Methods·Thomas DörnerPeter E Lipsky
Oct 16, 2010·Nature Reviews. Immunology·Michael R Ehrenstein, Clare A Notley
Jan 12, 2011·The Journal of Experimental Medicine·Daniel O GriffinThomas L Rothstein
May 28, 2011·Arthritis and Rheumatism·Edward M VitalPaul Emery
Jun 10, 2011·Journal of Molecular Modeling·Xinying Li
Nov 15, 2011·Arthritis Research & Therapy·Thomas DörnerPeter E Lipsky
Nov 24, 2011·The Journal of Experimental Medicine·Daniel O Griffin, Thomas L Rothstein
Dec 21, 2011·The Journal of Experimental Medicine·Marc DescatoireSandra Weller
Dec 21, 2011·The Journal of Experimental Medicine·Martin Perez-AndresMenno C van Zelm
Mar 14, 2012·The Journal of Experimental Medicine·Claude-Agnès Reynaud, Jean-Claude Weill
May 29, 2012·Molecular Medicine·Daniel O Griffin, Thomas L Rothstein
Jun 2, 2012·Frontiers in Immunology·Daniel O Griffin, Thomas L Rothstein
Jan 3, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·João Furtado, David A Isenberg

❮ Previous
Next ❯

Citations

Sep 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Bettina BudeusRalf Küppers
Nov 7, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tâm D QuáchThomas L Rothstein
Mar 24, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mariana SilvaRobert Sackstein
Jan 18, 2019·Expert Review of Clinical Immunology·Vasiliki KoulouriClio P Mavragani
Feb 16, 2019·American Journal of Reproductive Immunology : AJRI·Yaozhu LengNardhy Gomez-Lopez
Nov 30, 2018·Journal of Applied Physiology·Guillaume SpielmannJohn Campbell
Nov 9, 2019·Cellular & Molecular Immunology·Zunling LiCheng Cheng Zhang
Jan 8, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tâm D QuáchThomas L Rothstein
Jun 15, 2019·Scientific Reports·Frederico Alisson-SilvaAdriane R Todeschini
Jun 2, 2016·Antibodies·Karl J Lackner, Nadine Müller-Calleja
Nov 14, 2019·International Journal of Hematology·Yuki Kageyama, Naoyuki Katayama
Apr 4, 2019·Frontiers in Immunology·Nely Rodriguez-ZhurbenkoAna M Hernandez
May 1, 2021·Antibody Therapeutics·Mi DengCheng Cheng Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.