PMID: 7537825Jan 1, 1995Paper

Human CD5+ B lymphocytes (B-1 cells) decrease in peripheral blood during pregnancy

Journal of Reproductive Immunology
N M BhatN N Teng

Abstract

Pregnancy is a unique immunologic state where a natural homeostasis exists between antigenically different tissues. Several earlier studies have addressed the fluctuations in the number and/or function of lymphocytes, including B cells during pregnancy, but changes within the subsets of B lymphocytes, conventional (CD5-) and B-1 (CD5+), have not been addressed. Here we demonstrate that the frequency of B-1 cells decreases dramatically during pregnancy, whereas the frequency of conventional B cells remains relatively constant. The missing B-1 cells return to pre-pregnancy levels 8-10 weeks after parturition. The polyreactive autoantibodies secreted by B-1 cells have been implicated in autoimmunity and immune regulation. The possible role of B-1 cells during pregnancy will be discussed in that context.

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Citations

Jun 1, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Dorota Darmochwal-KolarzJan Oleszczuk
Jun 28, 2000·The Journal of Obstetrics and Gynaecology Research·F ChishimaK Satoh
May 1, 1997·American Journal of Reproductive Immunology : AJRI·M WatanabeN Amino
Jun 24, 2014·Cellular & Molecular Immunology·Nardhy Gomez-LopezMarcia Arenas-Hernandez
Jul 13, 2014·Human Reproduction Update·Azure N FaucetteKang Chen
Jan 29, 2013·American Journal of Reproductive Immunology : AJRI·Damián MuzzioFederico Jensen
Jan 5, 2013·Clinical and Experimental Immunology·T G NguyenJ M Morris
Jul 6, 2014·Journal of Immunology Research·Alicia Martínez-VareaAntonio Pellicer
Nov 28, 2014·Biology of Reproduction·Petra Clara ArckMaría Emilia Solano
Oct 19, 2017·International Journal of Molecular Sciences·Anne Schumacher
Jan 10, 2019·American Journal of Reproductive Immunology : AJRI·Jorge LimaMaria Leandro
Oct 15, 2019·International Reviews of Immunology·Sulagna DuttaNazmul Haque
Oct 6, 2020·Frontiers in Immunology·Ingrid AnemanLana McClements
Nov 20, 2016·American Journal of Reproductive Immunology : AJRI·Soheil TavakolpourSaeid Delshad
Jan 11, 2020·Frontiers in Immunology·Nardhy Gomez-LopezAdi L Tarca
Nov 3, 2020·Frontiers in Immunology·Bahaa Abu-RayaPascal M Lavoie
Jul 19, 2020·International Immunopharmacology·Roghayeh JafarpourMorteza Motallebnezhad
Apr 4, 2021·International Journal of Molecular Sciences·Marta MagattiOrnella Parolini

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