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Human CD8+ T cells from TB pleurisy respond to four immunodominant epitopes in Mtb CFP10 restricted by HLA-B alleles

PloS One

Dec 19, 2013

Li LiChangyou Wu

Abstract

CD8(+) T cells are essential for host defense to Mycobacterium tuberculosis (Mtb) infection and identification of CD8(+) T cell epitopes from Mtb is of importance for the development of effective peptide-based diagnostics and vaccines. We previously demonstrated that the secreted 10-KDa...read more

Mentioned in this Paper

Saponin
Flow Cytometry
T-Lymphocyte
Bacterial Proteins
IL7R gene
Tumor Necrosis Factor-alpha
Tuberculosis
Lysosomal-Associated Membrane Protein 2
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
CD8A wt Allele
1
20
Paper Details
References
  • References39
  • Citations2
1234

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Human CD8+ T cells from TB pleurisy respond to four immunodominant epitopes in Mtb CFP10 restricted by HLA-B alleles

PloS One

Dec 19, 2013

Li LiChangyou Wu

PMID: 24349220

DOI: 10.1371/journal.pone.0082196

Abstract

CD8(+) T cells are essential for host defense to Mycobacterium tuberculosis (Mtb) infection and identification of CD8(+) T cell epitopes from Mtb is of importance for the development of effective peptide-based diagnostics and vaccines. We previously demonstrated that the secreted 10-KDa...read more

Mentioned in this Paper

Saponin
Flow Cytometry
T-Lymphocyte
Bacterial Proteins
IL7R gene
Tumor Necrosis Factor-alpha
Tuberculosis
Lysosomal-Associated Membrane Protein 2
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
CD8A wt Allele
1
20

Related Papers

Paper Details
References
  • References39
  • Citations2
1234
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