PMID: 6974160Aug 1, 1981Paper

Human cell lines express multiple populations of Ia-like molecules

Human Immunology
J M PesandoS F Schlossman

Abstract

Three monoclonal antibodies have been used to isolate Ia-like antigens from three human cell lines; two of which are thought to be homozygous at the HLA-D/DR locus. Complete extraction of the Ia antigens identified by one antibody leaves those recognized by the two remaining antibodies in three parallel sets of experiments, indicating that the antigenic determinants recognized by these antibodies are present on three different populations of Ia molecules from cells of single individuals. These three populations of Ia-like molecules may reflect serologic variants of the product of a single genetic locus or may represent the products of as many as three nonallelic genetic regions. Demonstration of the existence of these multiple populations of Ia-like molecules on presumed homozygous typing cells indicates that this antigenic system is much more complex than has been generally realized. Further study may clarify the relationship between HLA-D/DR type and susceptibility to a variety of diseases and ultimately lead to better matches and improved survival for allogenic transplants. Since the HLA-D region is intimately involved in regulation of the immune response and susceptibility to a variety of diseases, use of monoclonal antibod...Continue Reading

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Citations

Jun 1, 1996·Human Immunology·E J Yunis
Jan 1, 1986·Annals of the New York Academy of Sciences·G CordierJ P Revillard
Jan 1, 1986·Annals of the New York Academy of Sciences·G CordierJ P Revillard
Jan 1, 1989·Leukemia Research·J M PesandoM A Stucki

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