Human cellular immune response against Giardia lamblia 5 years after acute giardiasis

The Journal of Infectious Diseases
Kurt HanevikNina Langeland

Abstract

Clinical and epidemiological studies have suggested the development of acquired immunity in individuals previously infected with Giardia lamblia. However, there are no data on the long-term cellular immunity and genotype cross-reactivity. An outbreak of assemblage B giardiasis in a nonendemic area made it possible to evaluate the long-term cellular mediated immunity and its specificity toward the 2 Giardia assemblages known to infect humans. Peripheral blood mononuclear cells from 19 individuals infected with Giardia assemblage B 5 years previously and from 10 uninfected controls were cultured with antigens from assemblage A and B Giardia trophozoites for 6 days. Cell-mediated immunity was measured by a (3)H-thymidine proliferation assay and flow cytometric analysis of activation markers HLA-DR, CD45RO, CD25, and CD26 in T-cell subsets. Proliferation responses were significantly elevated in the group previously exposed to Giardia for nearly all Giardia antigens tested. Individual responses toward Giardia trophozoite whole cell, cytosolic, and excretory-secretory antigens from both assemblages correlated well. Activation marker responses were mainly seen in CD4 T cells. G. lamblia infection induces long-term, albeit variable, ce...Continue Reading

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Related Concepts

Antigens, Protozoan
Giardiasis
HLA-DR Antigens
Lymphocyte Activation
CD4 Positive T Lymphocytes
Giardia lamblia
CD45RCAntigens
Dipeptidyl-Peptidase IV
Cell Proliferation
Interleukin 2 Receptor, Alpha

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