Human cerebral collateral arteriole function in subjects with normal cognition, mild cognitive impairment, and dementia

American Journal of Physiology. Heart and Circulatory Physiology
Raymond Q MigrinoThomas G Beach

Abstract

Clinical and preclinical studies have suggested a link between cardiovascular disease and dementia disorders, but the role of the collateral brain circulation in cognitive dysfunction remains unknown. We aimed to test the hypothesis that leptomeningeal arteriole (LMA) function and response to metabolic stressors differ among subjects with dementia, mild cognitive impairment (MCI), and normal cognition (CN). After rapid autopsy, LMAs were isolated from subjects with CN ( n = 10), MCI ( n = 12), or dementia [ n = 42, Alzheimer's disease (AD), vascular dementia (VaD), or other dementia], and endothelial and smooth muscle-dependent function were measured at baseline and after exposure to β-amyloid (2 μM), palmitic acid (150 μM), or medin (5 μM) and compared. There were no differences among the groups in baseline endothelial function (maximum dilation to acetylcholine, CN: 74.1 ± 9.7%, MCI: 67.1 ± 4.8%, AD: 74.7 ± 2.8%, VaD: 72.0 ± 5.3%, and other dementia: 68.0 ± 8.0%) and smooth muscle-dependent function (CN: 93.4 ± 3.0%, MCI: 83.3 ± 4.1%, AD: 91.8 ± 1.7%, VaD: 91.7 ± 2.4%, and other dementia: 87.9 ± 4.9%). There was no correlation between last cognitive function score and baseline endothelial or smooth muscle-dependent function. ...Continue Reading

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Citations

Jun 23, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Peter TothZoltan Ungvari
Sep 3, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Raymond Q MigrinoThomas G Beach
May 14, 2020·Biophysical Journal·Scott YoungerFernando T Arce
Oct 13, 2020·Dementia and Geriatric Cognitive Disorders·Rui Kleber Martins-FilhoOctavio Pontes-Neto

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Methods Mentioned

BETA
transgenic

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