Abstract
Clinical and preclinical studies have suggested a link between cardiovascular disease and dementia disorders, but the role of the collateral brain circulation in cognitive dysfunction remains unknown. We aimed to test the hypothesis that leptomeningeal arteriole (LMA) function and response to metabolic stressors differ among subjects with dementia, mild cognitive impairment (MCI), and normal cognition (CN). After rapid autopsy, LMAs were isolated from subjects with CN ( n = 10), MCI ( n = 12), or dementia [ n = 42, Alzheimer's disease (AD), vascular dementia (VaD), or other dementia], and endothelial and smooth muscle-dependent function were measured at baseline and after exposure to β-amyloid (2 μM), palmitic acid (150 μM), or medin (5 μM) and compared. There were no differences among the groups in baseline endothelial function (maximum dilation to acetylcholine, CN: 74.1 ± 9.7%, MCI: 67.1 ± 4.8%, AD: 74.7 ± 2.8%, VaD: 72.0 ± 5.3%, and other dementia: 68.0 ± 8.0%) and smooth muscle-dependent function (CN: 93.4 ± 3.0%, MCI: 83.3 ± 4.1%, AD: 91.8 ± 1.7%, VaD: 91.7 ± 2.4%, and other dementia: 87.9 ± 4.9%). There was no correlation between last cognitive function score and baseline endothelial or smooth muscle-dependent function. ...Continue Reading
References
Feb 1, 1993·Neurology·G C RománA Hofman
Oct 1, 1996·Journal of Neuroscience Methods·R PriorG Pavlakovic
Nov 5, 1997·Journal of Neuropathology and Experimental Neurology·B T Hyman, J Q Trojanowski
Apr 6, 2002·Stroke; a Journal of Cerebral Circulation·J C de la Torre
Sep 7, 2002·Stroke; a Journal of Cerebral Circulation·Donald R Royall
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·George OsolNatalia I Gokina
Jun 17, 2003·Nature Medicine·Rashid DeaneBerislav Zlokovic
Sep 27, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Alex E RoherThomas G Beach
Oct 25, 2003·Stroke; a Journal of Cerebral Circulation·Mariana BroziciBerend Hillen
Jul 22, 2004·Neurological Research·Walter KalbackAlex E Roher
Feb 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Francis KimElaine W Raines
Oct 6, 2006·Acta Neuropathologica·Thomas G BeachAlex E Roher
May 13, 2009·Journal of Alzheimer's Disease : JAD·Jurgen A H R ClaassenRong Zhang
Jul 23, 2011·Stroke; a Journal of Cerebral Circulation·Philip B GorelickUNKNOWN American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Counci
Oct 4, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Raymond Q MigrinoParameswaran Hari
Mar 13, 2012·The Journal of Clinical Investigation·Rashid DeaneBerislav V Zlokovic
May 23, 2012·PloS One·Jesse M HunterAlex E Roher
Oct 30, 2013·Journal of Alzheimer's Disease : JAD·Markus MorawskiSteffen Roßner
May 31, 2014·Stroke; a Journal of Cerebral Circulation·David S LiebeskindUNKNOWN SWIFT Investigators
Jul 9, 2014·Journal of Neuroscience Methods·Seth TruranRaymond Q Migrino
Jan 27, 2015·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Thomas G BeachMarwan N Sabbagh
Feb 28, 2015·Diabetes·Juraj KoskaPeter D Reaven
Dec 5, 2015·Biophysical Journal·Hannah A DaviesJillian Madine
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Seth TruranRaymond Q Migrino
Apr 23, 2016·Stroke; a Journal of Cerebral Circulation·Siu-Lung ChanMarilyn J Cipolla
Sep 2, 2017·Cardiovascular Research·Raymond Q MigrinoJillian Madine
Citations
Jun 23, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Peter TothZoltan Ungvari
Jan 14, 2020·Journal of the American Heart Association·Nina KaramanovaRaymond Q Migrino
Sep 3, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Raymond Q MigrinoThomas G Beach
May 14, 2020·Biophysical Journal·Scott YoungerFernando T Arce
Oct 13, 2020·Dementia and Geriatric Cognitive Disorders·Rui Kleber Martins-FilhoOctavio Pontes-Neto