PMID: 7832302Jan 1, 1995

Human chest wall function while awake and during halothane anesthesia. II. Carbon dioxide rebreathing

Anesthesiology
D O Warner, M A Warner

Abstract

Changes in the distribution of respiratory drive to different respiratory muscles may contribute to respiratory depression produced by halothane. The aim of this study was to examine factors that are responsible for halothane-induced depression of the ventilatory response to carbon dioxide rebreathing. In six human subjects, respiratory muscle activity in the parasternal intercostal, abdominal, and diaphragm muscles was measured using fine-wire electromyography electrodes. Chest wall motion was determined by respiratory impedance plethysmography. Electromyography activities and chest wall motion were measured during hyperpnea produced by carbon dioxide rebreathing while the subjects were awake and during 1 MAC halothane anesthesia. Halothane anesthesia significantly reduced the slope of the response of expiratory minute ventilation to carbon dioxide (from 2.88 +/- 0.73 (mean +/- SE) to 2.01 +/- 0.45 l.min-1.mmHg-1). During the rebreathing period, breathing frequency significantly increased while awake (from 10.3 +/- 1.4 to 19.7 +/- 2.6 min-1, P < 0.05) and significantly decreased while anesthetized (from 28.8 +/- 3.9 to 21.7 +/- 1.9 min-1, P < 0.05). Increases in respiratory drive to the phrenic motoneurons produced by rebreath...Continue Reading

References

Feb 22, 2005·Journal of Clinical Anesthesia·Robert A SmithRafael V Miguel
Oct 17, 1998·Progress in Neurobiology·S Iscoe
Jun 11, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Maninder KalraRaouf S Amin
Aug 6, 2000·Journal of Thoracic Imaging·T IwasawaS Matsubara
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·L PuybassetJ J Rouby
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·L M MalbouissonJ J Rouby
May 19, 1998·Anesthesia and Analgesia·D O WarnerE L Ritman
Feb 28, 2001·Anesthesia and Analgesia·J AyoubC Préfaut
Jun 1, 2007·Nihon Hoshasen Gijutsu Gakkai zasshi·Shigemi KitamuraMitoshi Akiyama
Nov 25, 2011·Current Opinion in Anaesthesiology·Gerardo TusmanJuraj Sprung
Jul 1, 1996·Anesthesiology·D O WarnerE L Ritman
Oct 1, 1996·Anesthesiology·D O WarnerE L Ritman
Oct 1, 1995·Anesthesiology·D O WarnerE L Ritman
Feb 5, 1999·Acta Anaesthesiologica Scandinavica. Supplementum·K Rehder

Citations

Apr 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·L D PengellyA S Rebuck
May 1, 1979·British Journal of Anaesthesia·J G JonesB Minty
May 1, 1976·Journal of Applied Physiology·J P DerenneJ Milic-Emili
Mar 1, 1975·Journal of Applied Physiology·M D AltoseA P Fishman
May 1, 1991·Journal of Applied Physiology·M A SchroederG A Farkas
Feb 1, 1991·Journal of Applied Physiology·D O WarnerK Rehder
Mar 1, 1990·Journal of Applied Physiology·A De TroyerM Gorini
Jun 1, 1989·Anesthesiology·S KrayerE L Ritman
May 1, 1985·Journal of Applied Physiology·M J KimJ T Sharp
Oct 1, 1986·Journal of Applied Physiology·N R PrabhakarN S Cherniack
May 1, 1985·Journal of Applied Physiology·A MierA De Troyer
Nov 1, 1987·Journal of Applied Physiology·B DureuilJ M Desmonts
Oct 1, 1974·Journal of Applied Physiology·A S RebuckL D Pengelly
Sep 1, 1974·Anesthesiology·A B Froese, A C Bryan
Sep 1, 1969·Anesthesiology·T F HornbeinP Parmentier
Mar 1, 1966·Journal of Applied Physiology·R V LourençoA P Fishman
Sep 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J Mead, S H Loring
Sep 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·A De Troyer, M Estenne
Nov 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·H GautierJ H Gaudy
Oct 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J PolacheckM Younes
Jun 1, 1994·Journal of Applied Physiology·D O WarnerE L Ritman
Apr 1, 1994·Anesthesiology·G HedenstiernaB Brismar
Mar 1, 1993·Journal of Applied Physiology·P A EastonA E Grassino

Related Concepts

Surface Electromyography
Structure of Intercostal Muscle
Plethysmography, Impedance
Halothane
Expiration, Function
Entire Diaphragm
Respiratory Muscles
Entire Chest Wall
Insufflation Anesthesia
Motor Neurons

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.