Human chorionic gonadotrophin immunoactivity in cystic intracranial tumours

Clinical Endocrinology
J HoneggerR Fahlbusch

Abstract

With regard to intracranial tumours, elevated hCG in CSF or serum has been considered to be specific for germ-cell tumours. Recently however, elevated hCG has also been shown to be present in cyst fluid and CSF of patients with craniopharyngiomas. While germ-cell tumours are generally non-cystic, the aim of our study was to determine the significance of hCG in cystic intracranial lesions. In a prospective study, hCG immunoactivity and subunits of hCG were measured in cyst fluid, CSF, and serum of patients harbouring intracranial cyst lesions. hCG immunoactivity was measured in cyst fluid and serum samples of 42 patients. CSF samples were available from 12 patients with craniopharyngiomas. In order to fully characterize the hCG immunoactivity, we used immunoradiometric assays for total hCG activity (measuring both intact hCG and the free beta-subunit of hCG), and those specific for intact, dimeric hCG (hCG), free beta-subunit of hCG (hCG beta) and free alpha-subunit. Furthermore, immunostaining of tumour tissue was performed using monoclonal antibodies directed against the free beta-subunit of hCG. Total hCG immunoactivity was markedly elevated in cyst fluid of all 17 craniopharyngiomas (range 36.7-4558 IU/I; normal < 5 IU/I). M...Continue Reading

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Citations

May 2, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ibrahim QaddoumiAmar Gajjar
Sep 25, 2014·Surgical Neurology International·Yasuyuki KinoshitaKaoru Kurisu
Mar 19, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Claudia DesiderioGavino Faa
Apr 23, 2013·Acta neurochirurgica·P BourdillonE Jouanneau
Mar 13, 2016·European Journal of Medical Research·Mingming HuFeng Gu
Feb 4, 2012·Pediatric Blood & Cancer·Jeffrey AllenIan Pollack
Nov 4, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Yasuyuki KinoshitaKaoru Kurisu
Apr 11, 2003·Pacing and Clinical Electrophysiology : PACE·Richard F MillerLaszlo Littmann
Mar 18, 2006·Endocrine Reviews·Niki KaravitakiJohn A H Wass
Jul 1, 1997·The Journal of Clinical Endocrinology and Metabolism·J J MukherjeeA B Grossman
Apr 18, 2017·Brain Pathology·Luca MassimiClaudia Desiderio
Jul 29, 1998·Annals of Clinical Biochemistry·C M Sturgeon, E J McAllister
May 1, 2021·Cancers·Melina de Moraes Santos OliveiraMaria Cristina Cintra Gomes-Marcondes

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