Human chorionic gonadotropin administration is associated with high pregnancy rates during ovarian stimulation and timed intercourse or intrauterine insemination

Reproductive Biology and Endocrinology : RB&E
Mohamed F MitwallyRobert F Casper

Abstract

There are different factors that influence treatment outcome after ovarian stimulation and timed-intercourse or intrauterine insemination (IUI). After patient age, it has been suggested that timing of insemination in relation to ovulation is probably the most important variable affecting the success of treatment. The objective of this study is to study the value of human chorionic gonadotropin (hCG) administration and occurrence of luteinizing hormone (LH) surge in timing insemination on the treatment outcome after follicular monitoring with timed-intercourse or intrauterine insemination, with or without ovarian stimulation. Retrospective analysis of 2000 consecutive completed treatment cycles (637 timed-intercourse and 1363 intrauterine insemination cycles). Stimulation protocols included clomiphene alone or with FSH injection, letrozole (an aromatase inhibitor) alone or with FSH, and FSH alone. LH-surge was defined as an increase in LH level > or =200% over mean of preceding two days. When given, hCG was administered at a dose of 10,000 IU. The main outcome was clinical pregnancy rate per cycle. Higher pregnancy rates occurred in cycles in which hCG was given. Occurrence of an LH-surge was associated with a higher pregnancy r...Continue Reading

Associated Clinical Trials

Jan 19, 2011·Senait Fisseha, MD, JD, Senait Fisseha, MD, JD

References

Mar 15, 1979·The New England Journal of Medicine·M Curie-CohenS Shapiro
Sep 1, 1990·Fertility and Sterility·C A FedermanS S Shapiro
Jun 1, 1989·American Journal of Obstetrics and Gynecology·R Lloyd, C B Coulam
Apr 9, 2002·Fertility and Sterility·Mohamed Farouk M Mitwally, Robert F Casper
Feb 20, 2003·Archives of Gynecology and Obstetrics·Mohamed A AboulgharHesham G Al-Inany
Feb 28, 2003·Expert Opinion on Investigational Drugs·Mohamed F M Mitwally, Robert F Casper

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Citations

Apr 9, 2014·Reproductive Biology and Endocrinology : RB&E·Birgit JatzkoJohannes Ott
Aug 2, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·R MatorrasAntonia Exposito
Nov 30, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Amir WiserTogas Tulandi

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Methods Mentioned

BETA
pregnancy test

Software Mentioned

SigmaStat

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