Human chorionic gonadotropin induces nitric oxide synthase mRNA in mouse peritoneal macrophages

Biochemical and Biophysical Research Communications
H M Kim, Y H Moon

Abstract

We examined the effects of human chorionic gonadotropin (hCG) on the production of nitric oxide (NO) by mouse peritoneal macrophages. hCG had no effect on NO synthesis by itself, whereas recombinant interferon-gamma (rIFN-gamma) alone had modest activity. When hCG was used in combination with rIFN-gamma, there was a marked cooperative induction of NO synthesis in a dose-dependent manner. The optimal effect of hCG on NO synthesis was shown at 6 h after treatment with rIFN-gamma. This increase in NO synthesis was reflected as increased amount of inducible NO synthase (iNOS) mRNA. NG-monomethyl-L-arginine, and arginase inhibited rIFN-gamma-plus-hCG-induced NO production. On the basis of these observations, we conclude that hCG activates expression of iNOS mRNA in mouse peritoneal macrophages accompanied by NO accumulation via pathway dependent on L-arginine in the culture medium.

Citations

Oct 13, 2006·Antioxidants & Redox Signaling·Anna M BarronRalph N Martins
Sep 17, 2002·Biological & Pharmaceutical Bulletin·Hwan-Suck ChungHyung-Min Kim
Oct 9, 2008·Canadian Journal of Physiology and Pharmacology·Hyo-Jin AnSeung-Heon Hong
Mar 12, 2016·General and Comparative Endocrinology·Rohini R NairKiran Singh
May 27, 2003·American Journal of Reproductive Immunology : AJRI·Y M ZhangZ M Lei
May 23, 2014·Frontiers in Immunology·Anne SchumacherAna Claudia Zenclussen
May 13, 1999·Immunopharmacology and Immunotoxicology·H M KimE H Lee
Jul 13, 2007·Journal of Leukocyte Biology·Hui WanRebecca C M Kiekens
Jul 21, 2005·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·H-J AnH-M Kim
Sep 30, 2008·Immunopharmacology and Immunotoxicology·Su-Jin KimSeung-Heon Hong
Mar 7, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hwan-Suck ChungHyung-Min Kim
Jan 5, 2000·Journal of Ethnopharmacology·H M KimN H An
Mar 23, 2000·International Journal of Immunopharmacology·H M KimC H Kim
Jul 10, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hyun-Ja JeongHyung-Min Kim
Jul 16, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Hwan-Suck ChungHyung-Min Kim

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