Human chorionic gonadotropin profile for women with ectopic pregnancy

Obstetrics and Gynecology
Celso SilvaKurt T Barnhart

Abstract

To analyze serial human chorionic gonadotropin (hCG) levels in women presenting to the emergency department who were ultimately confirmed to have ectopic pregnancies. Human chorionic gonadotropin levels were obtained over time until definitive diagnosis. To be included, women had to have at least 2 hCG measurements. Human chorionic gonadotropin curves were characterized and their slopes calculated. Two hundred women received diagnoses of ectopic pregnancy with the help of serial hCG values and were included in the study. No curve adequately characterized the pattern of hCG values so attention was focused on the initial 2 values. The median slope of log hCG among all subjects was 0.11 (25% increase in 2 days). However, 60% of subjects had an initial rise in hCG, and 40% had an initial fall. The rise in hCG for women with ectopic pregnancies (0.28; 75% increase in 2 days) was slower than the mean increase reported for a viable intrauterine pregnancy. The decline in hCG for women with ectopic pregnancies (-0.225; 27% decline in 2 days) was slower than the mean reported for completed spontaneous abortion. However, 20.8% of women presented with a rise in hCG values similar to the minimal rise for women with a viable gestation, and 8...Continue Reading

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Citations

Jul 25, 2009·The New England Journal of Medicine·Kurt T Barnhart
Nov 28, 2008·Obstetrics and Gynecology·Kurt T BarnhartJ L Kulp
Jul 6, 2011·The Journal of Family Planning and Reproductive Health Care·Vanitha N SivalingamAndrew W Horne
Dec 17, 2008·Women's Health·Emma Kirk, Tom Bourne
Dec 17, 2008·Women's Health·Jennifer L Kulp, Kurt T Barnhart
Jul 6, 2013·Women's Health·Ngozi C Orazulike, Justin C Konje
Apr 12, 2013·Contraception·E Steve LichtenbergUNKNOWN Society of Family Planning
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