PMID: 8971045Dec 1, 1996Paper

Human chromosome 6- and 11-encoded factors support human immunodeficiency virus type 1 Rev function in A9 cells

Journal of Virology
R R ShuklaA Kumar

Abstract

The precise mechanism of Rev-mediated expression of human immunodeficiency virus (HIV-1) late genes is not well characterized. We recently proposed a requirement for HIV-1 Rev responsive element (RRE) RNA binding host nuclear proteins in Rev function. In this report, using a transient transfection assay of Rev function, we further demonstrate the role of host cell factors in HIV-1 Rev function. Murine A9 cells, which are inefficient in forming RRE-host protein ribonucleoprotein complexes, are also inefficient in supporting Rev function. We also show that host cell factor(s) encoded by human chromosomes 6 and 11 can support HIV-1 Rev-mediated expression of unspliced viral mRNAs in murine A9 cells.

References

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Jan 31, 1991·The New England Journal of Medicine·W C Greene
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Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·X B LuM L Hammarskjöld
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