Human cleavage-stage embryo vitrification is comparable to slow-rate cryopreservation in cycles of assisted reproduction.

Journal of Assisted Reproduction and Genetics
Martin Graham WildingBrian Dale

Abstract

To compare embryo survival, pregnancy and implantation rates after cryopreservation of human cleavage-stage embryos with slow-rate cryopreservation or vitrification. 262 patients, attending for assisted reproduction, were prepared for oocyte retrieval using standard controlled ovarian hyperstimulation protocols. Excess embryos were cryopreserved on day 3 either by vitrification, or slow-rate cryopreservation in a programmable freezer. Cycles of thawing were monitored for thaw efficiency, pregnancy and implantation rates. Clinical pregnancy and implantation rates were highly comparable between cycles in which day 3 embryos were thawed either after slow-rate cryopreservation or vitrification. These data suggest that vitrification of human embryos during assisted reproduction cycles achieves comparable success rates to fresh cycles and therefore can be applied in the laboratory of assisted reproduction.

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Citations

May 16, 2013·Reproductive Biology and Endocrinology : RB&E·Nina N DesaiTommaso Falcone
Apr 30, 2014·BioMed Research International·János KoncSándor Cseh
Apr 23, 2014·Journal of Assisted Reproduction and Genetics·Yee Shen ChongSadhana Nadarajah
Jan 11, 2016·Journal of Assisted Reproduction and Genetics·N KaartinenH Tinkanen
Jan 9, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jacob LevronShai E Elizur
Apr 15, 2015·Journal de gynécologie, obstétrique et biologie de la reproduction·J F GriveauK Morcel
Jun 4, 2014·Fertility and Sterility·Kai Mee WongSjoerd Repping
Aug 1, 2016·Reproductive Biology and Endocrinology : RB&E·Elia Fernandez GallardoSophie Debrock
Jul 12, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Jianfeng YaoXiaoyu Yang
Sep 25, 2017·Journal of Assisted Reproduction and Genetics·MeiFang ZengLiuMing Li
Oct 28, 2019·Reproductive Biology and Endocrinology : RB&E·Francesco CapodannoLorenzo Aguzzoli
Jul 8, 2011·Current Opinion in Obstetrics & Gynecology

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