PMID: 11926746Apr 3, 2002Paper

Human CMV-IGIV (CytoGam) neutralizes human cytomegalovirus (HCMV) infectivity and prevents intracellular signal transduction after HCMV exposure

Transplant Infectious Disease : an Official Journal of the Transplantation Society
K A AndreoniE S Huang

Abstract

Pretreatment of human cytomegalovirus (HCMV) with human hyperimmune globulin (CytoGam) in human embryonic lung (HEL) fibroblast culture showed successful inhibition of infectivity, and decreased extracellular viral titers and extracellular viral DNA. CytoGam prevented HCMV from inducing intracellular activation of NF-kappaB, Sp-1, and P13-K signaling pathways and the production of immediate-early (IE), early (E), and late (L) viral proteins. CytoGam neutralization of HCMV in this cell culture model prevented the earliest known signal transduction events (NF-kappaB, Sp-1, P13-K activation) after viral specific glycoproteins bind to their cognate cell membrane receptors, suggesting that this agent contains highly effective neutralizing antibodies against HCMV.

References

Oct 1, 1983·Antimicrobial Agents and Chemotherapy·E C MarE S Huang
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Aug 1, 1997·The Journal of General Virology·W A BresnahanT Albrecht
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Jul 30, 1999·Biochemical and Biophysical Research Communications·P D PeltonT P Burris
Feb 15, 2001·The Journal of General Virology·R A JohnsonE S Huang

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Citations

Jun 26, 2009·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Kylie A O'BrienPaul A Komesaroff
Jun 18, 2016·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Karen Bilton, Chris Zaslawski
Feb 18, 2017·Deutsches Ärzteblatt International·Horst BuxmannKlaus Friese
Mar 1, 2017·Deutsches Ärzteblatt International·Horst BuxmannKlaus Friese

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