Human CMV infection induces 5-lipoxygenase expression and leukotriene B4 production in vascular smooth muscle cells

The Journal of Experimental Medicine
Hong QiuJesper Z Haeggström

Abstract

Leukotrienes (LTs) are powerful proinflammatory lipid mediators that may play a central role in cardiovascular diseases, including arteriosclerosis, myocardial infarction, and stroke. Owing to restricted expression of 5-lipoxygenase (5-LO), the enzyme required for their synthesis, LTs are almost exclusively produced by myeloid cells. Here, we report that human cytomegalovirus (HCMV) infection of human vascular smooth muscle cells (SMCs) increases 5-LO mRNA levels by up to 170-fold in a dose- and time-dependent manner. Infected cells expressed 5-LO protein, as shown by immunohistochemistry, enabling them to synthesize bioactive LTB(4). HCMV-infected vascular SMCs expressing 5-LO protein were readily detected in tissue samples from CMV-infected patients with inflammatory bowel disease or AIDS. Thus, pathogen-induced LT production in HCMV-infected tissues may contribute to local inflammation, consistent with the ability of HCMV to control cellular and immunological functions. HCMV-induced LT biosynthesis in SMCs offers a molecular mechanism to explain HCMV-induced pathogenesis in inflammatory diseases.

References

Nov 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·B B Wentworth, L French
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·U Janssen-TimmenA J Habenicht
Mar 1, 1993·Coronary Artery Disease·P C LeeV J Dzau
Jan 1, 1996·Transplant International : Official Journal of the European Society for Organ Transplantation·T MorimotoY Yamaoka
Jan 1, 1996·Transplant International : Official Journal of the European Society for Organ Transplantation·F L LiC A Bruggeman
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·L WrightN F Voelkel
Mar 31, 2001·The American Journal of Gastroenterology·M CottoneL Pagliaro
Jan 5, 2002·The Biochemical Journal·Ying-Yi ZhangJoseph Loscalzo
Mar 9, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Robert J AielloHenry J Showell
May 15, 2004·The Journal of Infectious Diseases·Louis FlamandJean Gosselin
Sep 3, 2004·Nature Reviews. Immunology·Andrew D Luster, Andrew M Tager
Sep 14, 2004·Current Opinion in Lipidology·Einar E Eriksson
Jan 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jean GosselinLouis Flamand
Jul 26, 2005·Nature Reviews. Drug Discovery·Colin D Funk
May 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hong QiuJesper Z Haeggström
Aug 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Marija RakonjacOlof Rådmark

❮ Previous
Next ❯

Citations

Dec 17, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sara Gredmark-RussCecilia Söderberg-Nauclér
Jul 4, 2013·Medical Microbiology and Immunology·Serena DelbuePasquale Ferrante
Sep 23, 2011·Chemical Reviews·Jesper Z Haeggström, Colin D Funk
Oct 1, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mensur DzabicCecilia Söderberg-Nauclér
Mar 26, 2009·Journal of the National Cancer Institute·Klas StrååtDawei Xu
Jun 6, 2012·Mediators of Inflammation·Mary K McCarthy, Jason B Weinberg
Dec 20, 2012·Circulation Research·Zhou YuGarret A FitzGerald
Sep 29, 2011·The Journal of Clinical Investigation·Ninib BaryawnoCecilia Söderberg-Nauclér
Oct 31, 2013·Virology Journal·Wai Mun LokeRaymond C S Seet
Apr 9, 2011·Herpesviridae·Stefania Varani, Maria Paola Landini
Jan 27, 2012·Arthritis Research & Therapy·Cecilia Söderberg-Nauclér
Jan 21, 2014·Basic Research in Cardiology·Koon-Chu YaiwCecilia Söderberg-Nauclér
Jan 19, 2012·Age·Richard MacaulaySian M Henson
Mar 29, 2014·Brain, Behavior, and Immunity·Denise Janicki-DevertsJos Bosch
Jan 1, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Cecilia Söderberg-Nauclér
Jun 19, 2016·Mechanisms of Ageing and Development·Cecilia Söderberg-NauclérAfsar Rahbar
Mar 27, 2012·The Journal of Allergy and Clinical Immunology·Sayed Mahdi MarashiVincent C Emery
Feb 24, 2015·World Journal of Experimental Medicine·Cecilia Söderberg-Nauclér, John Inge Johnsen
May 23, 2012·Expert Review of Clinical Immunology·Richard R WatkinsRaymund R Razonable
Jan 11, 2014·Expert Review of Anti-infective Therapy·Cecilia Söderberg-Nauclér
Sep 30, 2015·The Journal of General Virology·Rasmus K L GustafssonLynn M Butler
Oct 28, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Yung-Feng YenYi-Ming Arthur Chen
Apr 8, 2020·Acta Biochimica Et Biophysica Sinica·Wenbo Zhu, Shuangquan Liu
Apr 27, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anuran ChatterjeeMichael S Conte
Feb 23, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rosanna VescoviniPaolo Sansoni
Aug 16, 2018·The Journal of Clinical Investigation·Jesper Z Haeggström
Jun 17, 2019·Journal of Cancer Research and Clinical Oncology·Helena CostaCecilia Söderberg-Naucler
Jun 4, 2010·Journal of Immunotoxicology·Anatolii A ChumakJulia Yanko
Jan 18, 2013·Journal of Digestive Diseases·Meng XueJian Min Si
Nov 12, 2020·Journal of Medical Virology·Afsar RahbarCecilia Söderberg-Naucler
May 23, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Rui HeQian Cai
Apr 6, 2021·Frontiers in Cellular and Infection Microbiology·Kumari Asha, Neelam Sharma-Walia

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
transgenic

Software Mentioned

2100 Expert

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Hua ZhuT Shenk
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
R B Freeman
Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
C Söderberg-Nauclér
© 2021 Meta ULC. All rights reserved