PMID: 4292695Oct 27, 1967Paper

Human collagenase: identification and characterization of an enzyme from rheumatoid synovium in culture

Science
J M EvansonS M Krane

Abstract

Synovial tissue from patients with rheumatoid arthritis produces lysis of gels of reconstituted collagen fibrils in culture and releases soluble collagenase when cultured in collagen-free medium. Collagen molecules in solution at neutral pH at 20 degrees and 27 degrees C are cleaved by the synovial enzyme into (3/4) and (1/4) length fragments. In this respect the action of synovial enzyme is similar to that of amphibian collagenase and distinct from that of bacterial collagenase. At 37 degrees C reconstituted collagen fibrils and native fibers are attacked by the enzyme and further degraded to polypeptides of low molecular weight. These polypeptides are produced only after denaturation of the larger fragments, which occurs at temperatures near 37 degrees C.

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Citations

Apr 1, 1969·Arthritis and Rheumatism·E D HarrisS M Krane
Dec 1, 1969·Arthritis and Rheumatism·R KitridouK Hummeler
Jan 1, 1970·Arthritis and Rheumatism·E D HarrisS M Krane
Sep 1, 1970·Arthritis and Rheumatism
Mar 1, 1971·Arthritis and Rheumatism·J L GrandaA S Posner
May 1, 1974·Arthritis and Rheumatism·S M Krane
Sep 1, 1975·Arthritis and Rheumatism·I Kobayashi, M Ziff
Nov 1, 1975·Arthritis and Rheumatism·J M Lane, C Weiss
Jan 1, 1978·Arthritis and Rheumatism·C L MainardiE D Harris
Sep 1, 1978·Arthritis and Rheumatism·M G EhrlichH J Mankin
Jul 1, 1994·Research Communications in Molecular Pathology and Pharmacology·G Kweifio-OkaiM Cropley
May 1, 1977·The Laryngoscope·M Abramson, C C Huang
Apr 7, 1978·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·S Hayasaka, I Hayasaka
Jan 1, 1981·Springer Seminars in Immunopathology·J D Smiley, W L Hoffman
Feb 28, 1972·Biochimica Et Biophysica Acta·E D Harris, S M Krane
Aug 30, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·S LindyO Wegelius
Dec 15, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·H NakanoK Ito
May 1, 1970·Developmental Biology·M H Dresden, J Gross
Sep 1, 1971·Developmental Biology·J Gross, A B Bruschi
Aug 15, 1971·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·J W SimpsonB M Levy
May 5, 2004·Best Practice & Research. Clinical Rheumatology·Jean-Michel Dayer
Sep 28, 2001·Trends in Immunology·G OpdenakkerJ Van Damme
Oct 24, 1968·The New England Journal of Medicine·G S LazarusH M Fullmer
Oct 24, 1968·The New England Journal of Medicine
Sep 12, 1974·The New England Journal of Medicine·E D Harris, S M Krane
Jan 1, 1974·Acta Pathologica Japonica·G UsukuT Ogata
Jun 1, 1979·Annals of the Rheumatic Diseases·R W Jubb
Jun 1, 1980·Annals of the Rheumatic Diseases·E R Kuutti-SavolainenO Laitinen
Oct 1, 1981·Annals of the Rheumatic Diseases·S M Krane
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