PMID: 6972335Apr 1, 1981Paper

Human colonic mononuclear cells: studies of cytotoxic function

Gut
Z M FalchukI Machado

Abstract

We isolated lymphocytes from the lamina propria of colon from 19 patients with inflammatory bowel disease, colon cancer, and certain benign conditions to determine: (1) if these lymphocytes could mediate mitogen-induced (MICC) and spontaneous cell-mediated cytotoxicity (SCMC), and (2) if there were any differences in cytotoxic effectiveness which could relate to the underlying disease. We found that lamina propria lymphocytes functioned well in MICC reactions with phytohaemagglutinin, but not concanavalin A as the inducing mitogen (specific lysis 28 5% vs 5 3%). Lamina propria lymphocytes did not mediate SCMC (specific lysis 0.3%). Neither the presence of inflammation not the underlying disease of the patient influenced the cytotoxic activity. Peripheral blood lymphocytes from normal subjects and patients performed well in MICC assay with both phytohaemagglutinin and concanvalin A as the inducing mitogen and were equally effective in SCMC reactions.

References

Nov 1, 1979·Digestive Diseases and Sciences·M ChibaS ReMine
May 1, 1977·The Journal of Clinical Investigation·D M Bull, M A Bookman
Apr 1, 1978·Gut·R Clancy, A Pucci
Jan 1, 1973·International Archives of Allergy and Applied Immunology·F Wislöff, S S Fröland
Jul 1, 1974·Journal of Immunological Methods·M E Kaplan, C Clark
Sep 1, 1970·Cellular Immunology·P Perlmann, H Perlmann

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Citations

Sep 1, 1991·Journal of Gastroenterology and Hepatology·P G HoganW F Doe

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