Human Cord Blood B Cells Differ from the Adult Counterpart by Conserved Ig Repertoires and Accelerated Response Dynamics.

The Journal of Immunology : Official Journal of the American Association of Immunologists
B. BudeusMarc Seifert

Abstract

Neonatal and infant immune responses are characterized by a limited capability to generate protective Ab titers and memory B cells as seen in adults. Multiple studies support an immature or even impaired character of umbilical cord blood (UCB) B cells themselves. In this study, we provide a comprehensive molecular and functional comparison of B cell subsets from UCB and adult peripheral blood. Most UCB B cells have a mature, naive B cell phenotype as seen in adults. The UCB Ig repertoire is highly variable but interindividually conserved, as BCR clonotypes are frequently shared between neonates. Furthermore, UCB B cells show a distinct transcriptional program that confers accelerated responsiveness to stimulation and facilitated IgA class switching. Stimulation drives extensive differentiation into Ab-secreting cells, presumably limiting memory B cell formation. Humanized mice suggest that the distinctness of UCB versus adult B cells is already reflected by the developmental program of hematopoietic precursors, arguing for a layered B-1/B-2 lineage system as in mice, albeit our findings suggest only partial comparability to murine B-1 cells. Our study shows that UCB B cells are not immature or impaired but differ from their adu...Continue Reading

References

Apr 3, 1987·Science·R R HardyT Kishimoto
May 1, 1988·Arthritis and Rheumatism·M DauphinéeN Talal
Jun 1, 1985·The Journal of Experimental Medicine·K HayakawaL A Herzenberg
Mar 29, 1985·Science·R M PerlmutterL E Hood
Jan 1, 1983·The Journal of Experimental Medicine·K HayakawaL A Herzenberg
Feb 1, 1982·The Journal of Experimental Medicine·F Caligaris-CappioG Janossy
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·H H WortisD C Parker
Oct 1, 1993·Clinical Immunology and Immunopathology·A W GriffioenG T Rijkers
Jan 1, 1993·Annual Review of Immunology·A B Kantor, L A Herzenberg
Aug 17, 1999·The Journal of Experimental Medicine·K P Lam, K Rajewsky
Jan 6, 2001·American Journal of Perinatology·M Nesin, S Cunningham-Rundles
Mar 10, 2001·European Journal of Immunology·M PihlgrenC A Siegrist
Mar 20, 2002·The Journal of Experimental Medicine·Hedda WardemannRita Carsetti
Apr 12, 2003·The Journal of Experimental Medicine·Stephanie KruetzmannRita Carsetti
Aug 19, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Yuhui ShiKazuo Sugane
Nov 25, 2003·Clinical and Experimental Immunology·L Tasker, S Marshall-Clarke
Jul 2, 2004·Nature Reviews. Immunology·Becky AdkinsStuart Marshall-Clarke
Sep 15, 2005·The Journal of Experimental Medicine·Götz R A EhrhardtMax D Cooper
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria PihlgrenClaire-Anne Siegrist
May 3, 2006·The Journal of Infectious Diseases·Arnaud MarchantUNKNOWN Medical Research Council Gambia Twin Study Group
Mar 3, 2007·The Journal of Clinical Investigation·Yifat MerblIrun R Cohen
Apr 26, 2007·Nature Reviews. Immunology·Ofer Levy
May 17, 2008·Nature Reviews. Immunology·Andrea Cerutti
Feb 14, 2009·Nature Reviews. Immunology·Andrew J PollardPeter C Beverley
Feb 26, 2009·Nature Reviews. Immunology·Claire-Anne Siegrist, Richard Aspinall
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mirzokhid RakhmanovKlaus Warnatz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Repertoire Diversity

Antibody repertoire diversity and its role during natural infection is a prerequisite for molecular and structural elucidation of functionally protective immunity. Discover the latest insights into antibody diversity here.