Human cord blood CD133+ cells exacerbate ischemic acute kidney injury in mice

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Dylan BurgerKevin D Burns

Abstract

Acute kidney injury (AKI) in humans has few therapeutic options. In experimental models, administration of progenitor cells facilitates recovery from AKI. Human umbilical cord-derived CD133(+) progenitor cells promote endothelial repair in ischemic limb, heart and brain tissue. We examined the effects of human CD133(+) progenitor cells in bilateral ischemia-reperfusion (I/R) kidney injury in non-obese diabetic severe combined immunodeficient mice. CD133(+) cells from human cord blood were injected intravenously at the time of reperfusion and the extent of injury was determined by plasma biochemistry and kidney histology. In mice with I/R, fluorescently labeled CD133(+) cells were detected in blood 2 min after injection but decreased rapidly thereafter with no evidence of homing to the kidneys. In mice subjected to I/R, CD133(+) cells significantly increased plasma urea and Cr at 24 h compared to vehicle- or CD133(-) cell-treated mice. CD133(+) cells exacerbated tubular necrosis and apoptosis, increased plasma tumor necrosis factor-α and increased kidney neutrophil infiltration. In contrast, CD133(+) cells did not affect tubular cell proliferation. Administration of CD133(+) cells to FVB/N mice post-I/R also augmented kidney inj...Continue Reading

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Citations

Feb 1, 2014·Current Opinion in Organ Transplantation·Patricia A Murray, Adrian S Woolf
Jan 17, 2014·Journal of Nephrology·Daniel PatschanGerhard Anton Müller
Jun 16, 2015·The American Journal of Pathology·Dylan BurgerKevin D Burns
Sep 4, 2015·Canadian Journal of Kidney Health and Disease·Samuel A SilverJeffrey G Dickhout
Jul 3, 2018·Frontiers in Medicine·Adriana Torres CrignaKaren Bieback
Nov 7, 2019·International Journal of Molecular Sciences·Joan Oliva
May 17, 2013·American Journal of Physiology. Renal Physiology·Daniel PatschanGerhard A Müller

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