Human coronary thrombus formation is associated with degree of plaque disruption and expression of tissue factor and hexokinase II

Circulation Journal : Official Journal of the Japanese Circulation Society
Nozomi OkuyamaYujiro Asada

Abstract

Atherosclerotic plaque thrombogenicity is a critical factor that affects thrombus formation and the onset of acute myocardial infarction (AMI). The aim of this study was to identify the vascular factors involved in thrombus formation and AMI onset. Culprit lesions in 40 coronary arteries with thrombi at autopsy after lethal AMI and non-cardiac death (asymptomatic plaque disruption) were analyzed on histology. Thrombus size, ratio of thrombus to lumen area, length of plaque disruption, and immunopositive areas for tissue factor (TF) and hexokinase (HK)-II were significantly larger in coronary arteries with AMI than with asymptomatic plaque disruption. The size of coronary thrombus positively correlated with the length of plaque disruption (r=0.80) and with immunopositive areas for TF (r=0.38) and HK-II (r=0.40). Because both M1 and M2 macrophages express TF and HK-II in symptomatic plaques, we assessed TF and HK-II expression in M1- and M2-polarized macrophages. The expression of TF was increased and that of HK-II was decreased in M2-, compared with M1-polarized THP-1 macrophages. Inhibiting glycolysis enhanced TF expression in the macrophages partly via hypoxia inducible factor-1α. The degree of plaque disruption and expression...Continue Reading

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Citations

Oct 27, 2018·Journal of Cellular Physiology·Dingding CaoJianxin Wu
Dec 14, 2018·Current Medicinal Chemistry·Sara N GarciaM Matilde Marques
Oct 24, 2018·Research and Practice in Thrombosis and Haemostasis·Yuki WatanabeYujiro Asada
Dec 11, 2020·Journal of Atherosclerosis and Thrombosis·Masanori NishimuraYujiro Asada

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