Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice

Virology
Hélène JacomyPierre J Talbot

Abstract

The notion that an infectious respiratory pathogen can damage the central nervous system (CNS) and lead to neurological disease was tested using a human respiratory coronavirus, the OC43 strain of human coronavirus (HCoV-OC43). First, primary cell cultures were used to determine the susceptibility of each type of neural cells to virus infection. Neurons were the target cells, undergoing degeneration during infection, in part due to apoptosis. Second, neuropathogenicity was investigated in susceptible mice. Intracerebral inoculation of HCoV-OC43 into BALB/c mice led to an acute encephalitis with neuronal cell death by necrosis and apoptosis. Infectious virus was apparently cleared from surviving animals, whereas viral RNA persisted for several months. Some of the animals surviving to acute encephalitis presented an abnormal limb clasping reflex and a decrease in motor activity starting several months post-infection. These results suggest that viral persistence could be associated with an increased neuronal degeneration leading to neuropathology and motor deficits in susceptible individuals.

References

May 1, 1992·Annals of Neurology·R S MurrayG F Cabirac
Sep 6, 1985·Science·S RestaJ D Siegel
Jun 1, 1980·The Journal of Cell Biology·K D McCarthy, J de Vellis
Jan 1, 1980·Journal of Medical Virology·H Riski, T Hovi
Nov 29, 1996·The Journal of Biological Chemistry·B I Giasson, W E Mushynski
Mar 17, 2000·Proceedings of the Society for Experimental Biology and Medicine·G Herbein, W A O'Brien
Sep 12, 2000·Journal of Virology·N ArbourP J Talbot
Mar 13, 2001·Annual Review of Immunology·L G Guidotti, F V Chisari
Sep 25, 2002·Clinics in Laboratory Medicine·Dennis L Kolson
Nov 26, 2002·The Journal of Infectious Diseases·Roberta L DeBiasiKenneth L Tyler
Dec 12, 2002·Journal of Neurovirology·Patrick L McGeer, Edith G McGeer
Apr 25, 2003·Lancet·J S M PeirisUNKNOWN SARS study group
Aug 7, 2003·Neurobiology of Disease·Ben Roediger, Patricia J Armati
Aug 12, 2003·Trends in Immunology·David A Padgett, Ronald Glaser
Aug 15, 2003·World Journal of Gastroenterology : WJG·Qing-He NieQin Su
Oct 3, 2003·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Joshua S Rest, David P Mindell
Nov 1, 2003·Virology·Hélène Jacomy, Pierre J Talbot
Mar 20, 2004·Emerging Infectious Diseases·Kwok-Kwong LauKwok-Yuen Yuen
Jul 29, 2004·Journal of Virology·Julien R St-JeanPierre J Talbot
Mar 16, 2005·Journal of Virology·J D RempelD L Gruol

❮ Previous
Next ❯

Citations

Jun 6, 2009·Schizophrenia Bulletin·Emily G SeveranceRobert H Yolken
Feb 2, 2010·Emerging Infectious Diseases·Nicola PrincipiSusanna Esposito
Feb 13, 2016·Nature Reviews. Drug Discovery·Alimuddin ZumlaKwok-Yung Yuen
Nov 7, 2009·Clinics in Laboratory Medicine·Brigitte A Wevers, Lia van der Hoek
Jun 22, 2018·Journal of Virology·Mathieu DubéPierre J Talbot
May 18, 2020·Journal of Neurovirology·Ali SepehrinezhadSajad Sahab Negah
Jul 21, 2020·AIDS Research and Human Retroviruses·Lena Al-HarthiDavid A Bennett
Sep 2, 2020·Journal of Neurology·Maryline SanterreBassel E Sawaya
Nov 13, 2018·Frontiers in Cellular Neuroscience·Karen BohmwaldAlexis M Kalergis
May 20, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Joy D IroegbuOmamuyovwi M Ijomone
Jan 8, 2014·The Journal of General Virology·Samuel R DominguezKathryn V Holmes
Sep 26, 2020·Frontiers in Neurology·Gilmara Gomes de AssisEugene V Gasanov
Jul 25, 2016·Diseases·Yvonne Xinyi LimDing Xiang Liu
Sep 16, 2020·Children·Carl E Stafstrom, Lauren L Jantzie
Jul 7, 2020·Frontiers in Neurology·Jianhan HuangLiangxue Zhou
Jul 14, 2020·Frontiers in Neurology·Mohamed KhatebMaryam Muqary
Jul 30, 2020·Journal of Neural Transmission·Peter Riederer, Volker Ter Meulen
Aug 2, 2020·Journal of Neurovirology·Susan Morgello
Sep 2, 2020·International Journal of Molecular Sciences·Natasha IrreraFrancesco Squadrito
Oct 6, 2020·SN Comprehensive Clinical Medicine·Mason ChackoRicardo Cáceda
Aug 21, 2020·Neurology·Pedro J Serrano-Castro
Oct 6, 2020·Frontiers in Immunology·Ritu Mishra, Akhil C Banerjea
Jul 30, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yassine YachouSaid Ait Benali
Jul 15, 2020·Neurocritical Care·Ghazal AghagoliSarah A Murphy
Oct 20, 2020·Brain Communications·Karen RitchieTam Watermeyer

❮ Previous
Next ❯

Methods Mentioned

BETA
FCS
PCR

Related Concepts

Related Feeds

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Acute Hemorrhagic Leukoencephalitis

Acute hemorrhagic leukoencephalitis is a rare form of acute disseminated encephalomyelitis characterized by acute inflammation in the brain and spinal cord that causes demyelination and bleeding. It is often fatal, although treatment with immunosuppressives and plasma exchange can be helpful. Find the latest research on acute hemorrhagic leukoencephalitis here.