Human cost burden of exposure to endocrine disrupting chemicals. A critical review

Archives of Toxicology
Gregory G Bond, Daniel R Dietrich

Abstract

Recently published papers have alleged that exposures to endocrine disrupting chemicals (EDCs) are causing substantial disease burdens in the EU and US and are consequently costing society hundreds of billions of dollars annually. To date, these cost estimates have not undergone adequate scientific scrutiny, but nevertheless are being used aggressively in advocacy campaigns in an attempt to fundamentally change how chemicals are tested, evaluated and regulated. Consequently, we critically evaluated the underlying methodology and assumptions employed by the chief architects of the disease burden cost estimates. Since the vast majority of their assigned disease burden costs are driven by the assumption that "loss of IQ" and "increased prevalence of intellectual disability" are caused by exposures to organophosphate pesticides (OPPs) and brominated flame retardants (PBDEs), we have taken special care in describing and evaluating the underlying toxicology and epidemiology evidence that was relied upon. Unfortunately, our review uncovered substantial flaws in the approach taken and the conclusions that were drawn. Indeed, the authors of these papers assumed causal relationships between putative exposures to EDCs and selected disease...Continue Reading

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Citations

Jul 9, 2020·Environmental Health : a Global Access Science Source·Axel MiePhilippe Grandjean
Feb 13, 2020·Nature Communications·Beate LeppertTobias Polte
Apr 5, 2019·Environmental Health : a Global Access Science Source·Axel MiePhilippe Grandjean
Jan 17, 2020·International Journal of Environmental Research and Public Health·Jian YuBin Liu
Mar 16, 2021·Frontiers in Endocrinology·Fritzie T Celino-BradyAndre P Seale

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