Human cytomegalovirus and Epstein-Barr virus in etiopathogenesis of apical periodontitis: a systematic review

Journal of Endodontics
Aleksandar Jakovljevic, M Andric

Abstract

During the last decade, a hypothesis has been established that human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) may be implicated in the pathogenesis of apical periodontitis. The aim of this review was to analyze the available evidence that indicates that HCMV and EBV can actually contribute to the pathogenesis of periapical lesions and to answer the following focused question: is there a relationship between HCMV and EBV DNA and/or RNA detection and the clinical features of human periapical lesions? The literature search covered MEDLINE, Science Citation Index Expanded (SCIexpanded), Scopus, and The Cochrane Library database. Quantitative statistical analysis was performed on the pooled data of HCMV and EBV messenger RNA transcripts in tissues of symptomatic and asymptomatic periapical lesions. The electronic database search yielded 48 hits from PubMed, 197 hits from Scopus, 40 hits from Web of Science, and 1 from the Cochrane Library. Seventeen cross-sectional studies have been included in the final review. The pooled results from quantitative systematic method analysis showed no statistically significant relationship between the presence of HCMV and EBV messenger RNA transcripts (P = .083 and P = .306, respectively)...Continue Reading

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Citations

Dec 26, 2015·Journal of Lasers in Medical Sciences·Nasim ChiniforushAbbas Bahador
Oct 6, 2015·Journal of Endodontics·Aleksandar JakovljevicJelena Milasin
Apr 14, 2016·Journal of Endodontics·Ibrahim Ethem Yaylali, Tayfun Alaçam
Jun 16, 2015·International Endodontic Journal·S M OzbekT Demiray
Oct 2, 2019·Acta Odontologica Scandinavica·Aleksandar JakovljevicJelena Milasin
Mar 14, 2020·Journal of Periodontal Research·Javier Enrique BoteroAdolfo Contreras
Sep 3, 2017·International Endodontic Journal·E PetitjeanP Lambrechts
Oct 16, 2018·Frontiers in Immunology·Afsar R NaqviSalvador Nares
Feb 16, 2021·Archives of Oral Biology·Juliana D BronzatoBrenda P F A Gomes
Jan 23, 2021·International Endodontic Journal·C LoureiroR C Jacinto
Apr 16, 2021·Journal of Dental Sciences·Aleksandar Jakovljevic, Jelena Milasin

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