PMID: 11920815Mar 29, 2002Paper

Human cytomegalovirus hyperimmune globulin not only neutralizes HCMV infectivity, but also inhibits HCMV-induced intracellular NF-kappaB, Sp1, and PI3-K signaling pathways

Journal of Medical Virology
K A AndreoniEng-Shang Huang

Abstract

Inhibition of virus-induced intracellular signaling pathways and viral infectivity are our ultimate goals in the development of effective antiviral agents to control human cytomegalovirus (HCMV) infections. The HCMV hyperimmune globulin may meet such criteria. In a human embryonic lung (HEL) fibroblast culture model, pretreatment of Towne strain HCMV with HCMV hyperimmune globulin was shown to inhibit viral infectivity successfully, as measured by a standard plaque assay. The extracellular viral titers and extracellular viral DNA, as measured by plaque assay and PCR, respectively, were also decreased. In addition, the HCMV hyperimmune globulin prevented HCMV from inducing the intracellular activation of NF-kappaB, Sp-1, and PI3-K signaling pathways. The PI3-K pathway was examined by following phosphorylation (activation) of two of its downstream kinases, Akt and p70S6K. HCMV hyperimmune globulin also prevented the production of immediate early, early, and late viral proteins. These studies show that HCMV hyperimmune globulin neutralization of HCMV prevents the earliest known events observed after viral envelope glycoproteins bind their cell membrane receptors, i.e., NF-kappaB, Sp-1 and PI3-K activation. This suggests that HCMV ...Continue Reading

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Citations

Feb 16, 2010·Journal of Thrombosis and Thrombolysis·Milan PopovićYves Laumonnier
Dec 14, 2011·Journal of Thrombosis and Thrombolysis·Milan PopovićEsma R Isenović
Jan 1, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Andreas SchwingshacklChristopher M Waters
Jan 18, 2005·Antiviral Research·David L EversEng-Shang Huang
Apr 14, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N G RouphaelG M Lyon
Mar 9, 2007·Journal of Immunological Methods·Anna Maria AbaiMary K Wloch
Jan 22, 2005·Journal of Medicinal Chemistry·Hosup YeoYung-Chi Cheng

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