Human cytomegalovirus induced pseudotumor of upper gastrointestinal tract mucosa: effects of long-term chronic disease?

Journal of Medical Virology
Luca Reggiani BonettiCristian Palmiere

Abstract

Human cytomegalovirus-induced lesions resembling malignancies have been described in the gastrointestinal tract and include ulcerated or exophytic large masses. The aim of this study was to review the cases registered in the databases of two academic hospitals and formulate a hypothesis concerning the pathogenic mechanisms responsible for cytomegalovirus-induced pseudotumor development. All the diagnoses of human cytomegalovirus infections of the upper gastrointestinal tract recorded from 1991 to 2013 were reviewed. Cases of mucosal alterations misdiagnosed endoscopically as malignancies were selected. Large ulcers occurring in the stomach (three cases) and an irregular exophytic mass at the gastro-jejunal anastomosis were misdiagnosed endoscopically as malignancies (4 cases out of 53). Histologically, all lesions reflected hyperplastic mucosal changes with a prevalence of epithelial and stroma infected cells, without signs of cell atypia. The hypothesis presented is that the development of human cytomegalovirus-induced pseudotumors may be the morphological expression of chronic mucosa damage underlying long-term infection.

References

Feb 24, 2001·The American Journal of Gastroenterology·S Y Xiao, J Hart
Aug 28, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Antonio MaioranaNicola Bellini
Aug 22, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Theodoros KelesidisJorge Fleisher
Sep 2, 2009·Internal Medicine·Takashi HimotoShoichi Senda
Jun 23, 2011·Scandinavian Journal of Gastroenterology·Luca Reggiani BonettiAntonio Maiorana
Jan 1, 2011·International Medical Case Reports Journal·Dhyan RajanPaul Mustacchia
May 24, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J-H KoJ-H Song

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