Human cytomegalovirus induces a distinct innate immune response in the maternal-fetal interface

Virology
Yiska WeisblumDana G Wolf

Abstract

The initial interplay between human cytomegalovirus (HCMV) and innate tissue response in the human maternal-fetal interface, though crucial for determining the outcome of congenital HCMV infection, has remained unknown. We studied the innate response to HCMV within the milieu of the human decidua, the maternal aspect of the maternal-fetal interface, maintained ex vivo as an integral tissue. HCMV infection triggered a rapid and robust decidual-tissue innate immune response predominated by interferon (IFN)γ and IP-10 induction, dysregulating the decidual cytokine/chemokine environment in a distinctive fashion. The decidual-tissue response was already elicited during viral-tissue contact, and was not affected by neutralizing HCMV antibodies. Of note, IFNγ induction, reflecting immune-cell activation, was distinctive to the maternal decidua, and was not observed in concomitantly-infected placental (fetal) villi. Our studies in a clinically-relevant surrogate human model, provide a novel insight into the first-line decidual tissue response which could affect the outcome of congenital infection.

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Citations

Nov 4, 2016·Medical Microbiology and Immunology·Bodo Plachter
Sep 15, 2017·Pathogens and Disease·Moises León-JuárezEnrique Reyes-Muñoz
Dec 30, 2016·Journal of Clinical Microbiology·Alda SaldanDavide Abate
Mar 17, 2017·F1000Research·Vincent C Emery, Tiziana Lazzarotto
Aug 7, 2017·F1000Research·Philippe Le Bouteiller, Armand Bensussan
Jan 13, 2019·Science Immunology·Stephanie E AnderCarolyn B Coyne
Oct 30, 2020·Journal of Virology·Anna ChudnovetsIrina Burd
Apr 28, 2021·Mucosal Immunology·Evgeniya V Shmeleva, Francesco Colucci
Jul 3, 2021·Frontiers in Immunology·Zachary W BerkebileCraig J Bierle
Apr 11, 2019·Journal of Innate Immunity·Michael Z ZuluClive M Gray

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