PMID: 9188651Jul 1, 1997Paper

Human cytomegalovirus induces interleukin-8 production by a human monocytic cell line, THP-1, through acting concurrently on AP-1- and NF-kappaB-binding sites of the interleukin-8 gene

Journal of Virology
T MurayamaK Matsushima

Abstract

Cytomegalovirus (CMV) infection induced interleukin-8 (IL-8) gene transcription in a human monocytic cell line, THP-1 cells, leading to IL-8 secretion. The functional analysis of the IL-8 gene revealed that both AP-1- and NF-kappaB factor-binding elements were involved in conferring the responsiveness to CMV. Moreover, electrophoretic mobility shift assays demonstrated that CMV induced the formation of NF-kappaB and AP-1 complexes. These results suggest that CMV activates these transcriptional factors, resulting in IL-8 gene expression.

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Citations

Mar 25, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J SzabóF D Tóth
Jan 19, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Q ShiK Xie
Nov 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Khalid S A Khabar, Stephen J Polyak
Apr 30, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Adrian Liston, Shaun McColl
Mar 6, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Naofumi Mukaida
Apr 30, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Li-Fu LiDeborah A Quinn
Jun 26, 2004·The Journal of General Virology·Martina LeisThomas Stamminger
Dec 18, 2004·The Journal of General Virology·Barbara ReinhardtDetlef Michel
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Jul 16, 2010·Journal of Neurochemistry·Shanshan ShenWandong Zhang
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