Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta

Journal of Virology
Takako TabataLenore Pereira

Abstract

Human cytomegalovirus (HCMV) is a major cause of birth defects that include severe neurological deficits, hearing and vision loss, and intrauterine growth restriction. Viral infection of the placenta leads to development of avascular villi, edema, and hypoxia associated with symptomatic congenital infection. Studies of primary cytotrophoblasts (CTBs) revealed that HCMV infection impedes terminal stages of differentiation and invasion by various molecular mechanisms. We recently discovered that HCMV arrests earlier stages involving development of human trophoblast progenitor cells (TBPCs), which give rise to the mature cell types of chorionic villi-syncytiotrophoblasts on the surfaces of floating villi and invasive CTBs that remodel the uterine vasculature. Here, we show that viral proteins are present in TBPCs of the chorion in cases of symptomatic congenital infection. In vitro studies revealed that HCMV replicates in continuously self-renewing TBPC lines derived from the chorion and alters expression and subcellular localization of proteins required for cell cycle progression, pluripotency, and early differentiation. In addition, treatment with a human monoclonal antibody to HCMV glycoprotein B rescues differentiation capacit...Continue Reading

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Citations

Nov 4, 2016·Medical Microbiology and Immunology·Bodo Plachter
Oct 28, 2016·American Journal of Obstetrics and Gynecology·Gianluca StrafaceMarco De Santis
Dec 27, 2017·Journal of Cellular Biochemistry·Qin ZhengQiu Yan
Nov 24, 2016·World Journal of Virology·Kevin J ZwezdarykDeborah E Sullivan
Nov 13, 2015·Journal of Virology·Wendy J van ZuylenWilliam D Rawlinson
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Apr 10, 2020·Prenatal Diagnosis·Adam W BartlettWilliam D Rawlinson
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Mar 17, 2017·F1000Research·Vincent C Emery, Tiziana Lazzarotto
Jan 11, 2020·Frontiers in Immunology·Caroline L AshleyBarry Slobedman
Nov 28, 2019·The Journal of Infectious Diseases·Nasim C SobhaniStephanie L Gaw
Mar 13, 2021·Reviews in Medical Virology·Krishneel SinghWilliam D Rawlinson
Jul 3, 2021·Frontiers in Immunology·Zachary W BerkebileCraig J Bierle
Oct 15, 2021·BMJ Case Reports·Claudia Salazar-SanchezWalter Ventura
Nov 25, 2021·The Journal of General Virology·Kadeem HydeBlair L Strang

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