Human cytomegalovirus inhibits cytokine-induced macrophage differentiation

Journal of Virology
Sara GredmarkC Söderberg-Nauclér

Abstract

Human cytomegalovirus (HCMV) infection in immunocompromised patients is associated with impaired immunological function. Blood monocytes, which differentiate into macrophage effector cells, are of central importance for immune reactivity. Here, we demonstrate that HCMV transiently blocks cytokine-induced differentiation of monocytes into functionally active phagocytic macrophages. In HCMV-treated cultures, the cells had classical macrophage markers but lacked the classical morphological appearance of macrophages and had impairments in migration and phagocytosis. Even at very low multiplicities of infection, macrophage differentiation was almost completely inhibited. The inhibition appeared to be mediated by a soluble factor released upon viral treatment of monocytes. Human immunodeficiency virus or measles virus had no such effects. These findings suggest that HCMV impairs immune function by blocking certain aspects of cytokine-induced differentiation of monocytes and demonstrate an efficient pathway for this virus to evade immune recognition that may have clinical implications for the generalized immunosuppression often observed in HCMV-infected patients.

References

Feb 1, 1992·The Journal of General Virology·J H SinclairJ G Sissons
Jun 1, 1992·Annals of Hematology·B Torok-StorbD Myerson
Sep 1, 1991·The Journal of General Virology·J Taylor-WiedemanJ H Sinclair
Dec 1, 1991·Journal of Virology·C E IbanezJ A Nelson
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P SimmonsB Torok-Storb
Jul 3, 1990·Journal of Immunological Methods·D BronP Stryckmans
Jun 23, 1989·JAMA : the Journal of the American Medical Association·M T GrattanN E Shumway
Dec 1, 1986·The Journal of General Virology·H ReiserR Braun
Nov 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·B B Wentworth, L French
Feb 1, 1984·The Journal of Infectious Diseases·L Einhorn, A Ost
Mar 1, 1993·Immunology Today·H W Ziegler-Heitbrock, R J Ulevitch
Jan 29, 1994·Lancet·W D DöckeH D Volk
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·K KondoE S Mocarski
Jun 1, 1994·Journal of Virology·E J MintonJ G Sissons
Feb 1, 1993·The Journal of General Virology·J Taylor-WiedemanJ H Sinclair
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·K KondoE S Mocarski
Dec 1, 1996·The Journal of General Virology·M MendelsonJ Sinclair
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·G HahnE S Mocarski
May 23, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A S KutzaG Bein
May 11, 1999·Journal of Virology·B Slobedman, E S Mocarski
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·S V KotenkoS Pestka
Nov 15, 2000·Cellular and Molecular Life Sciences : CMLS·D Naniche, M B Oldstone
Apr 6, 2001·Seminars in Immunology·W A LoenenE J Wiertz
Jul 20, 2001·Journal of Virology·C Söderberg-NauclérJ A Nelson
Jan 5, 2002·Journal of Virology·Juliet V SpencerThomas J Schall

❮ Previous
Next ❯

Citations

Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
Aug 20, 2005·Southern Medical Journal·Bertram W Roberts, Irina Cech
Aug 31, 2006·Journal of Virology·Jenny OdebergCecilia Söderberg-Nauclér
Mar 18, 2011·Journal of Virology·Andrea I LoewendorfPenelope C Kay-Jackson
Jan 16, 2010·Stroke; a Journal of Cerebral Circulation·Mitchell S V ElkindMyunghee C Paik
Apr 9, 2011·Herpesviridae·Stefania Varani, Maria Paola Landini
Feb 26, 2013·Immunobiology·Olesja FornaraCecilia Söderberg-Nauclér
Jan 14, 2016·Journal of Clinical Immunology·Fathiah S AmranPatricia Price
Nov 17, 2009·Molecular Immunology·Kok-Hooi YewChristopher Harrison
Jul 25, 2009·Clinical Transplantation·Konstantin Zedtwitz-LiebensteinMichael Frass
Dec 19, 2009·Periodontology 2000·Jørgen Slots
Oct 29, 2013·Virulence·Tomasz JarzembowskiAlicja Dębska-Ślizień
May 11, 2005·Biochemical and Biophysical Research Communications·Dagmar RiemannE Michael Danielsen
May 21, 2016·Journal of Pediatric Gastroenterology and Nutrition·Xinling XuCecilia Söderberg-Nauclér
Dec 13, 2006·Journal of Neuroscience Research·Jenny OdebergCecilia Söderberg-Nauclér
Jun 2, 2017·The Open Virology Journal·S PasquereauG Herbein
Mar 28, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Arnaud G L'HuillierAtul Humar
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kashif Aziz KhanGeorges Herbein
Aug 28, 2020·Frontiers in Cellular and Infection Microbiology·Chan-Ki MinAndrew D Yurochko

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.