PMID: 8970996Dec 1, 1996Paper

Human cytomegalovirus mtrII oncoprotein binds to p53 and down-regulates p53-activated transcription

Journal of Virology
S MuralidharL J Rosenthal

Abstract

The 79-amino-acid (79-aa) open reading frame (UL111a) gene within morphological transforming region II (mtrII) of human cytomegalovirus strain Towne has been shown to transform rodent cells in vitro (J. Thompson, J. Doniger, and L. J. Rosenthal, Arch. Virol. 136:161-172, 1994). Moreover, a translation termination linker (TTL) mutant of mtrII that coded for the first 49 aa of mtrII oncoprotein (designated TTL49) was sufficient for malignant transformation, whereas a TTL mutant that coded for the first 24 aa (designated TTL24) was not. The current study demonstrates the binding of mtrII oncoprotein to the tumor suppressor protein p53 both in vivo using transiently transfected cells and in vitro using labeled proteins. Furthermore, the C-terminally truncated mtrII protein TTL49, but not truncated protein TTL24, bound to p53. The mtrII binding domain mapped to the N-terminal region of p53, residues 1 to 106, with a critical region from aa 27 to 44, whereas the p53 binding domain of mtrII protein was the first 49 aa. Furthermore, mtrII inhibited p53-activated transcription, indicating its ability to alter p53-directed cellular regulatory mechanisms. mtrII oncoprotein was detected both in stably transfected NIH 3T3 cell lines and hum...Continue Reading

References

Mar 15, 1979·Nature·D P Lane, L V Crawford
Jul 15, 1979·Virology·M L RamirezL J Rosenthal
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S J KuerbitzM B Kastan
Aug 1, 1992·Journal of Virology·M A SublerS Deb
Sep 11, 1992·Nucleic Acids Research·F KashanchiJ N Brady
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·E SetoT Shenk
Nov 22, 1991·Science·H zur Hausen
Aug 1, 1991·The American Journal of Surgical Pathology·N AzumiH Battifora
Jul 5, 1991·Science·M HollsteinC C Harris
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D GinsbergM Oren
Mar 7, 1990·Journal of the National Cancer Institute·A A Schreier, J Gruber
Jan 1, 1989·Journal of Virology·R J JariwallaL J Rosenthal
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A RazzaqueL J Rosenthal
Nov 1, 1986·Journal of Virology·T el-BeikL J Rosenthal
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D A GallowayJ K McDougall
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D J ClantonL J Rosenthal
Jan 1, 1984·Journal of Virology·J A NelsonJ K McDougall
Sep 1, 1995·Genes & Development·S MaheswaranD A Haber
Aug 1, 1994·Molecular and Cellular Biology·P WangP Tegtmeyer
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·X W WangC C Harris
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·C Y ChenM B Kastan

❮ Previous
Next ❯

Citations

Feb 10, 2012·Neuro-oncology·Kristine DziurzynskiUNKNOWN HCMV and Gliomas Symposium
Apr 25, 1997·The Journal of Biological Chemistry·R B RayR Ray
Jul 9, 2002·Oncogene·Keng-Hsin LanShou-Dong Lee
Aug 22, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·Janaína L LeiteLaura S Ward
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·S V KotenkoS Pestka
Mar 25, 2004·The Journal of General Virology·Masaya TakemotoKoichi Yamanishi
Jun 26, 2020·Frontiers in Cellular and Infection Microbiology·Emma PooleMaria Cristina Carlan da Silva
Jul 2, 2011·Journal of Neuro-oncology·Alexander KofmanRoger Abounader
Nov 22, 2013·Journal of Virology·Melanie SchmidRamon A Gonzalez
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·E A FortunatoD H Spector
May 30, 2002·The Journal of Biological Chemistry·Sophie AllartChristian Davrinche
Dec 5, 2018·Frontiers in Cellular and Infection Microbiology·Ying FanRoberto Bruzzone
Jul 10, 1999·Journal of Virology·J J SwensonS C Kenney
Dec 19, 2002·Cytokine & Growth Factor Reviews·Sergei V Kotenko
Mar 30, 2000·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·S MuralidharL J Rosenthal
Jul 10, 1999·Clinical Microbiology Reviews·J DonigerL J Rosenthal
Sep 14, 2021·Molecular Oncology·Luigi Marongiu, Heike Allgayer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.