Human cytomegalovirus riding the cell cycle

Medical Microbiology and Immunology
Deborah H Spector

Abstract

Human cytomegalovirus (HCMV) infection modulates the host cell cycle to create an environment that is optimal for viral gene expression, DNA replication, and production of infectious virus. The virus mostly infects quiescent cells and thus must push the cell into G1 phase of the cell cycle to co-opt the cellular mechanisms that could be used for DNA synthesis. However, at the same time, cellular functions must be subverted such that synthesis of viral DNA is favored over that of the host. The molecular mechanisms by which this is accomplished include altered RNA transcription, changes in the levels and activity of cyclin-dependent kinases, and other proteins involved in cell cycle control, posttranslational modifications of proteins, modulation of protein stability through targeted effects on the ubiquitin-proteasome degradation pathway, and movement of proteins to different cellular locations. When the cell is in the optimal G0/G1 phase, multiple signaling pathways are altered to allow rapid induction of viral gene expression once negative factors have been eliminated. For the most part, the cell cycle will stop prior to initiation of host cell DNA synthesis (S phase), although many cell cycle proteins characteristic of the S/...Continue Reading

References

Jan 10, 1991·Nature·M GlotzerM W Kirschner
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·A SchulzeB Henglein
Oct 7, 1994·Cell·A Ciechanover
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·B HengleinC Bréchot
Feb 1, 1997·Journal of Virology·D Dittmer, E S Mocarski
Jan 1, 1997·Trends in Genetics : TIG·J Zwicker, R Müller
Jul 11, 1998·Cell·T J McGarry, M W Kirschner
Aug 8, 1998·Genes & Development·N Dyson
Aug 15, 1998·The Journal of Biological Chemistry·W A BresnahanE A Thompson
Oct 6, 1998·Annual Review of Biochemistry·A Hershko, A Ciechanover
Oct 9, 1999·Journal of Virology·L Wiebusch, C Hagemeier
Mar 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·M L HayashiT Shenk
Aug 10, 2000·Journal of Virology·J P CastilloT F Kowalik
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yoon-Jae Song, Mark F Stinski
Jun 13, 2002·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Hideo Nishitani, Zoi Lygerou
Jun 21, 2002·The Journal of General Virology·Ker R MarshallChris M Preston
Aug 3, 2002·Nature Reviews. Cancer·Karen H Vousden, Xin Lu
Nov 5, 2002·Journal of Virology·Emanuela NorisSanto Landolfo
Jan 14, 2003·EMBO Reports·Lüder WiebuschChristian Hagemeier
Dec 3, 2003·Molecular and Cellular Biology·Michela A TessariGuidalberto Manfioletti
Jan 28, 2004·Cell·Andrew W Murray
Apr 8, 2004·Physiological Genomics·Jean F ChallacombeThomas S Brettin

❮ Previous
Next ❯

Citations

Aug 21, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jiajia TangWolfram Brune
Dec 29, 2017·Clinical Obstetrics and Gynecology·Akila Subramaniam, William J Britt
Sep 25, 2019·Nature Microbiology·Ramona BusingerMichael Schindler
May 26, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Geovana BassoJose Osmar Medina-Pestana
Dec 3, 2018·FASEB BioAdvances·Zhenping ChenThomas Albrecht
Mar 18, 2019·Medical Microbiology and Immunology·Catharina MajerRenate König
Sep 11, 2019·Journal of Clinical Medicine·Florian Full, Armin Ensser
Feb 20, 2021·Journal of Clinical and Translational Hepatology·Teresa Da Cunha, George Y Wu
Mar 17, 2021·Proceedings of the National Academy of Sciences of the United States of America·Pooya Naseri-NosarThomas Shenk
Jul 3, 2021·Viruses·Nicole Mihelson, Dorian B McGavern
Jul 7, 2021·Journal of Hepatology·Valentina C SladkyAndreas Villunger
Nov 25, 2021·The Journal of General Virology·Kadeem HydeBlair L Strang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

© 2021 Meta ULC. All rights reserved