PMID: 16629416Apr 25, 2006Paper

Human demyelinating disease and the polyomavirus JCV

Multiple Sclerosis : Clinical and Laboratory Research
K Khalili, Martyn K White

Abstract

Many human neurological diseases involve demyelination of the central and/or peripheral nervous systems. These include the hereditary leukodystrophies--which have a genetic basis; multiple sclerosis (MS)--where the underlying cause of demyelination remains unknown; and progressive multifocal leukoencephalopathy (PML)--where the etiology is well-established as being viral. The human neurotropic polyomavirus--JC virus (JCV)--is the etiologic agent of PML, a fatal demyelinating disease of the central nervous system that occurs mainly in immunosuppressed patients, especially those with HIV/AIDS. JCV belongs to the polyomavirus family of tumor viruses that are characterized by non-enveloped icosahedral capsids containing small, circular, double-stranded DNA genomes. Serological studies have shown that JCV is widespread throughout the human population, but infections are usually restricted by the immune system, particularly cell-mediated immunity, causing the virus to enter a latent phase. An important corollary of this is that situations of severe immunosuppression may permit JCV to replicate and are thus a risk factor for PML.

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Citations

Sep 23, 2008·Multiple Sclerosis : Clinical and Laboratory Research·E IacobaeusEo Major
Mar 28, 2007·Journal of Cellular Physiology·Valentina CaraccioloPier Paolo Claudio
Mar 2, 2010·Expert Review of Neurotherapeutics·Klaus Lauer
May 1, 2010·Future Virology·A Sami SaribasMahmut Safak
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Dec 1, 2006·Der Nervenarzt·Peter Rieckmann, Peter Rieckmann
Feb 9, 2017·Infectious Agents and Cancer·Serena DelbuePasquale Ferrante
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Jun 10, 2009·Seminars in Cancer Biology·Melissa S Maginnis, Walter J Atwood

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