Human dendritic cells are less potent at killing Candida albicans than both monocytes and macrophages

Microbes and Infection
Mihai G NeteaBart Jan Kullberg

Abstract

Dendritic cells (DC) function as professional phagocytes to kill Candida albicans and subsequently present it to the adaptive immune system. Monocytes, macrophages and DC were generated from five individual donors and their Candida-killing capacity and cytokine release were assessed. Compared to monocytes and macrophages, DC from healthy volunteers were significantly less effective in C. albicans--stimulated cytokine release, killing of C. albicans blastoconidia and damaging of C. albicans hyphae. In conclusion, while important as antigen-presenting cells and initiators of the adaptive immune system, DC are poor in both intracellular killing and damaging of C. albicans hyphae. Effective handling of large numbers of C. albicans is the prime task of the innate immune system consisting of large numbers of neutrophils and monocytes.

References

Feb 1, 1978·The Journal of Clinical Investigation·R D DiamondW Jao
Aug 1, 1990·The American Journal of Medicine·N ImamS B Danforth
Sep 7, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M B EdmondR P Wenzel
May 12, 2000·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·J GuggenheimerT Orchard
Jul 30, 2002·Nature Immunology·Brian L KelsallPaul M Kaye
Mar 21, 2003·European Journal of Immunology·Alessandra CambiCarl G Figdor

❮ Previous
Next ❯

Citations

Jan 29, 2013·Medical Microbiology and Immunology·Pedro MiramónBernhard Hube
Aug 25, 2011·The Journal of Biological Chemistry·Chelsea L BueterStuart M Levitz
May 17, 2008·The Journal of Biological Chemistry·Alessandra CambiCarl G Figdor
Jan 20, 2011·Infection and Immunity·Dmitry A SolovievWilliam A Fonzi
Aug 19, 2014·Medical Microbiology and Immunology·Tilman E KlassertHortense Slevogt
Jun 14, 2013·Immunity & Ageing : I & a·Karen Henriette PinkeVanessa Soares Lara
Dec 14, 2011·Expert Review of Anti-infective Therapy·Ilse D JacobsenBernhard Hube
Aug 22, 2006·Expert Opinion on Biological Therapy·Alieke G VonkBart Jan Kullberg
Jul 22, 2006·Microbiology and Immunology·Alberto González-NovoJavier Jiménez
Mar 24, 2016·Microbial Pathogenesis·Thacianna Barreto Da CostaCélia Maria M B De Castro
Mar 19, 2015·Aging Clinical and Experimental Research·Magda Paula Pereira do NascimentoVanessa Soares Lara
Jun 12, 2012·Microbes and Infection·Paul LemireMariela Segura
Jun 10, 2010·FEMS Microbiology Reviews·Frank L van de VeerdonkBart Jan Kullberg
Jan 20, 2006·FEMS Immunology and Medical Microbiology·Masood A KhanMohammed Owais
Jul 6, 2007·FEMS Immunology and Medical Microbiology·Melanie WellingtonConstantine G Haidaris
Sep 22, 2015·Nature Reviews. Immunology·Mihai G NeteaFrank L van de Veerdonk
May 12, 2018·Nature Reviews. Disease Primers·Peter G PappasBart Jan Kullberg
Jul 31, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Samir JawharaDmitry A Soloviev
Jun 1, 2016·Journal of Biophotonics·Cláudio Daniel CerdeiraFelipe Fornias Sperandio
Feb 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dmitry A SolovievEdward F Plow
Jun 20, 2018·Frontiers in Immunology·Surabhi GoyalHortense Slevogt
Nov 18, 2018·Nature Communications·Bernard KanPascal M Lavoie
Feb 9, 2021·Frontiers in Cellular and Infection Microbiology·Truc Thi Huong DinhPatcharee Ritprajak
May 16, 2021·Current Opinion in Microbiology·Chetan V Jawale, Partha S Biswas
Aug 3, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Balaji PathakumariWeida Liu
Nov 12, 2005·Science·Rachael Z MurrayJennifer L Stow

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.