Human dendritic cells in allergic asthma and rhinitis

Médecine sciences : M/S
Antoine Froidure, C Pilette

Abstract

The role of dendritic cells (DC) in the pathogenesis of allergic asthma and rhinitis has been highlighted for 15 years. In this review, we summarize key findings concerning DC function in airway allergy and focus on studies performed in human. DC coming from allergic patients have specific characteristics, including significant expression of high affinity receptor for IgE as well as a propensity for Th2 responses induction following priming with allergen and/or epithelial cytokines. Mechanistic data concerning this DC dysfunction in asthma also provide perspectives for innovating therapies.

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Citations

Mar 25, 2016·Médecine sciences : M/S·Valérie JuliaDavid Dombrowicz
Jun 10, 2015·Journal of Immunological Methods·Kazem AshjaeiKarin Hoffmann-Sommergruber

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