Human dietary exposure to chemicals in sub-Saharan Africa: safety assessment through a total diet study

The Lancet. Planetary Health
Luc IngenbleekJean-Charles Leblanc

Abstract

Human dietary exposure to chemicals can result in a wide range of adverse health effects. Some substances might cause non-communicable diseases, including cancer and coronary heart diseases, and could be nephrotoxic. Food is the main human exposure route for many chemicals. We aimed to assess human dietary exposure to a wide range of food chemicals. We did a total diet study in Benin, Cameroon, Mali, and Nigeria. We assessed 4020 representative samples of foods, prepared as consumed, which covered more than 90% of the diet of 7291 households from eight study centres. By combining representative dietary surveys of countries with findings for concentrations of 872 chemicals in foods, we characterised human dietary exposure. Exposure to lead could result in increases in adult blood pressure up to 2·0 mm Hg, whereas children might lose 8·8-13·3 IQ points (95th percentile in Kano, Nigeria). Morbidity factors caused by coexposure to aflatoxin B1 and hepatitis B virus, and sterigmatocystin and fumonisins, suggest several thousands of additional liver cancer cases per year, and a substantial contribution to the burden of chronic malnutrition in childhood. Exposure to 13 polycyclic aromatic hydrocarbons from consumption of smoked fish a...Continue Reading

References

Sep 4, 2004·Environmental Health Perspectives·Yunyun GongChristopher P Wild
Dec 19, 2006·Lancet·P Grandjean, P J Landrigan
Jun 20, 2007·International Journal of Epidemiology·Paul C TurnerChristopher P Wild
Feb 23, 2010·Environmental Health Perspectives·Yan Liu, Felicia Wu
Dec 2, 2010·The Analyst·Yoshiki Tsukakoshi
Jun 12, 2013·Lancet·Robert E BlackUNKNOWN Maternal and Child Nutrition Study Group
Feb 22, 2014·Lancet Neurology·Philippe Grandjean, Philip J Landrigan
May 18, 2016·Maternal & Child Nutrition·Mercedes de Onis, Francesco Branca
Aug 22, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Luc IngenbleekJean-Charles Leblanc

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