Human disease associated with Clostridium perfringens enterotoxin

Reviews of Environmental Contamination and Toxicology
R R MeerD L Park

Abstract

Clostridium perfringens continues to be a common cause of food-borne disease. Characteristics of this organism that contribute to its ability to cause food-borne illness include the formation of heat-resistant spores that survive normal cooking/heating temperatures, a rapid growth rate in warm food, and the production of enterotoxin (CPE) in the human gut. Time and temperature abuse associated with food preparation contributes to the majority of outbreaks of C. perfringens food-borne disease. CPE-induced diarrhea has been reported in the absence of a defined food vehicle. These cases have been typically associated with the elderly and following a course of antibiotic therapy. The incidence of CPE-induced diarrhea may be expected to increase with the growing population of immunocompromised (disease-, treatment-, or age-induced) individuals. Clostridium perfringens has been implicated as a possible contributor to the development of SIDS in susceptible individuals. Specifically, it has been hypothesized that CPE acts as a triggering agent, initiating the events associated with the development of SIDS. Continued refinement of both immunoassays and molecular methods for toxin and gene detection, respectively, will facilitate their e...Continue Reading

Citations

Jun 25, 2013·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Miseon ParkFatemeh Rafii
Mar 4, 2010·International Journal of Environmental Health Research·Iván Natividad-BonifacioCarlos Vázquez-Salinas
Nov 19, 2011·Journal of Veterinary Internal Medicine·S L MarksJ S Weese
May 24, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·B SimoneS Anderson
Oct 14, 2003·The Veterinary Clinics of North America. Small Animal Practice·Stanley L Marks, Elizabeth J Kather

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