Human Diseases from Gain-of-Function Mutations in Disordered Protein Regions

Cell
Xiao-Han Li, M Madan Babu

Abstract

Although there is much focus on the impact of mutations on structured protein domains, less is known about their impact on unstructured regions. In this issue, Meyer et al. demonstrate that mutations resulting in the emergence of new short linear peptide motifs within intrinsically disordered protein regions can cause human genetic diseases by gain of function.

Citations

Jun 21, 2019·Journal of Cellular Biochemistry·Abdolreza GhoreishyAmir Ghaemmaghami
Apr 3, 2020·Journal of Biomolecular Structure & Dynamics·Aditya MittalIshan Singh
Jul 22, 2019·Nature Communications·Mohamed Ghadie, Yu Xia
Mar 7, 2021·Trends in Plant Science·Evi CeulemansAlain Goossens
Jun 3, 2021·International Journal of Molecular Sciences·Maria PetrosinoValerio Consalvi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.