Human dishevelled genes constitute a DHR-containing multigene family

Genomics
M V Semënov, M Snyder

Abstract

Three human genes encoding proteins homologous to Drosophila Dishevelled protein were cloned and characterized. Amino acid similarity between the different Dishevelled proteins is concentrated in three highly conserved regions. Two of these regions do not exhibit significant sequence similarity with other known proteins; the third is similar to the discs-large homology region, which was first found in a Drosophila Discs-large tumor suppressor protein (also known as GLGF or PDZ domain). We produced antibodies against human Dishevelled-2 and demonstrated that it is a phosphoprotein and can be detected in all cell lines and human embryonic tissues examined. Indirect immunofluorescence indicates that it is found throughout the cytoplasm. Our results indicate that the human dishevelled genes constitute a multigene family and that Dishevelled proteins are highly conserved among metazoans.

References

Jun 26, 1992·Cell·R Nusse, H E Varmus
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Jan 1, 1987·Methods in Enzymology·M SnyderR W Davis
Feb 1, 1989·The Journal of Cell Biology·M Kozak
Sep 1, 1995·Trends in Biochemical Sciences·M B Kennedy
Mar 1, 1995·Trends in Biochemical Sciences·C P Ponting, C Phillips
May 1, 1995·Genes & Development·S YanagawaR Nusse
Dec 1, 1994·Developmental Biology·D HerzlingerA M Brown
Aug 1, 1994·Current Opinion in Genetics & Development·B A Parr, A P McMahon
Sep 1, 1994·Differentiation; Research in Biological Diversity·S J Weber-HallT C Dale
Jan 6, 1994·Nature·E SiegfriedN Perrimon
Jan 1, 1994·Genes & Development·S TakadaA P McMahon
Feb 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R T Moon
Nov 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M TsangD J Sussman
Oct 1, 1996·Current Biology : CB·J Yang-SnyderR T Moon

❮ Previous
Next ❯

Citations

Aug 1, 2009·The Journal of Biological Chemistry·Takeshi TerabayashiHiroaki Miki
Jun 15, 2011·Zebrafish·Whitney M LumTerence J Van Raay
Feb 22, 2005·Journal of Biology·Keiji ItohSergei Y Sokol
Dec 14, 2001·Proceedings of the National Academy of Sciences of the United States of America·W ChenW E Miller
Nov 4, 2010·The Journal of Biological Chemistry·Ho-Jin LeeJie J Zheng
Feb 12, 2013·The Journal of Biological Chemistry·José M González-SanchoAnthony M C Brown
Mar 1, 2016·American Journal of Human Genetics·Janson J WhiteClaudia M B Carvalho
Aug 12, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Qiang WeiEn-Hua Wang
May 10, 2008·Pediatric Blood & Cancer·Kevin ChenAykut Uren
Dec 8, 2009·British Journal of Haematology·Ya-Wei QiangJohn D Shaughnessy
Mar 31, 2015·American Journal of Human Genetics·Janson WhiteClaudia M B Carvalho
Dec 10, 1999·Experimental Cell Research·E T Strovel, D J Sussman
Dec 22, 2012·Growth Factors·Kenyi Saito-DiazEthan Lee
Oct 3, 1999·Mechanisms of Development·M Boutros, M Mlodzik
Oct 28, 2011·Organogenesis·Laura L Yates, Charlotte H Dean
Oct 12, 2010·Cell Cycle·Daniele V F Tauriello, Madelon M Maurice
Mar 13, 2014·Biophysical Journal·Daniel G S CapellutoCarla V Finkielstein
Oct 28, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Francisco Pelegri
Mar 13, 2010·The Journal of Biological Chemistry·Hagit TurmRachel Bar-Shavit
May 29, 2007·Nature Structural & Molecular Biology·Thomas Schwarz-RomondMariann Bienz
Jun 27, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Vivianne W DingFrank McCormick
Jul 27, 2000·The Journal of Biological Chemistry·V W DingF McCormick
Jul 20, 1999·The Journal of Biological Chemistry·J S LeeS Yanagawa
Mar 12, 2003·Oncogene·Ya-Wei QiangStuart Rudikoff
Oct 29, 2004·The Journal of Biological Chemistry·Yoshimi EndoJeffrey S Rubin
Jul 4, 2007·Journal of Cell Science·Thomas Schwarz-RomondMariann Bienz
Sep 1, 2000·Brain Research. Brain Research Reviews·G V De Ferrari, N C Inestrosa
Dec 17, 2009·Cellular Signalling·Chan Gao, Ye-Guang Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

CZI Human Cell Atlas Seed Network

The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.