Human disorders of cortical development: from past to present

The European Journal of Neuroscience
Fiona FrancisJamel Chelly

Abstract

Epilepsy and mental retardation, originally of unknown cause, are now known to result from many defects including cortical malformations, neuronal circuitry disorders and perturbations of neuronal communication and synapse function. Genetic approaches in combination with MRI and related imaging techniques continually allow a re-evaluation and better classification of these disorders. Here we review our current understanding of some of the primary defects involved, with insight from recent molecular biology advances, the study of mouse models and the results of neuropathology analyses. Through these studies the molecular determinants involved in the control of neuron number, neuronal migration, generation of cortical laminations and convolutions, integrity of the basement membrane at the pial surface, and the establishment of neuronal circuitry are being elucidated. We have attempted to integrate these results with the available data concerning, in particular, human brain development, and to emphasize the limitations in some cases of extrapolating from rodent models. Taking such species differences into account is clearly critical for understanding the pathophysiological mechanisms associated with these disorders.

References

Feb 20, 1978·Anatomy and Embryology·M Marin-Padilla
Feb 1, 1976·Neuropädiatrie·K Jellinger, A Rett
Jul 8, 1988·Science·P Rakic
Jan 1, 1986·Brain & Development·I FerrerJ Campistol
Jul 1, 1984·American Journal of Medical Genetics·W B DobynsF Greenberg
Dec 1, 1982·American Journal of Medical Genetics·N FitchL Rochon
Jun 1, 1995·Neuropediatrics·W B Dobyns, C L Truwit
Sep 1, 1995·Trends in Neurosciences·V S CavinessR S Nowakowski
Aug 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·J M PinardO Dulac
Aug 1, 1993·American Journal of Medical Genetics·D J SpearrittD J Payton
Nov 1, 1995·Pediatric Neurology·A NakaiY Konishi
Sep 1, 1997·Nature Genetics·M BaesG P Mannaerts
May 20, 1998·Pediatric Neurology·L SztrihaM Varughese
Jun 9, 1998·Human Molecular Genetics·V des PortesC Beldjord
Aug 5, 1998·Journal of Neuropathology and Experimental Neurology·T L Kemper, M Bauman
Mar 10, 1999·Brain : a Journal of Neurology·A J HannanZ Molnár
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·C PesoldH J Caruncho
May 21, 1999·The European Journal of Neuroscience·S Baron-CohenS C Williams
May 29, 2000·Brain : a Journal of Neurology·S M Sisodiya
Jun 17, 2000·Trends in Neurosciences·C Y KuanP Rakic

❮ Previous
Next ❯

Citations

Nov 4, 2010·Acta Neuropathologica·Gaëlle FriocourtAnnie Laquerrière
Apr 23, 2013·Molecular Neurobiology·Borja L HolgadoMario Mellado
Feb 28, 2014·Nature Communications·Roberta AzzarelliFrançois Guillemot
Jan 9, 2009·Nature Medicine·Geraldine Kerjan, Joseph G Gleeson
May 25, 2006·European Journal of Human Genetics : EJHG·Jamel ChellyThierry Bienvenu
Jan 17, 2008·European Journal of Human Genetics : EJHG·Pietro ChiurazziGiovanni Neri
Jul 4, 2012·Proceedings of the National Academy of Sciences of the United States of America·Simone A FietzWieland B Huttner
Aug 2, 2008·Brain : a Journal of Neurology·Catherine Fallet-BiancoFiona Francis
May 16, 2009·Brain : a Journal of Neurology·Herbert HildebrandtRita Gerardy-Schahn
Feb 26, 2010·Cold Spring Harbor Perspectives in Biology·Oscar MarínLi-Huei Tsai
Apr 22, 2009·Development, Growth & Differentiation·Yoichi Kosodo, Wieland B Huttner
Apr 22, 2009·Development, Growth & Differentiation·Tomoko Iwata, Robert F Hevner
May 12, 2009·Biological Chemistry·Martina MühlenhoffRita Gerardy-Schahn
Apr 3, 2010·ASN Neuro·Luis R Hernández-MirandaFrancesca Chiara
Jan 10, 2013·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Soumya NarayanAkira Sawa
Feb 19, 2013·Trends in Neurosciences·Karl ZillesKatrin Amunts
Aug 23, 2012·Seminars in Fetal & Neonatal Medicine·Jin HuangKwong Wai Choy
Jan 24, 2012·Pediatric Neurology·Aman P S SohalVenkateswaran Ramesh
Nov 22, 2011·Behavioural Brain Research·Tamio FuruseShigeharu Wakana
Feb 4, 2011·Current Opinion in Genetics & Development·M Chiara Manzini, Christopher A Walsh
Aug 31, 2010·Progress in Pediatric Cardiology·Patrick S McQuillenDaniel J Licht
Jan 8, 2010·Current Opinion in Neurobiology·Manuel Valiente, Oscar Marín
Oct 30, 2009·Trends in Genetics : TIG·Xavier H Jaglin, Jamel Chelly
Nov 26, 2009·Progress in Neurobiology·Angela M KaindlPierre Gressens
Mar 7, 2009·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Alberto VerrottiPaola Iannetti
Mar 11, 2008·Behavioural Brain Research·Cyrille VaillendSerge Laroche
Mar 8, 2006·The European Journal of Neuroscience·Gaëlle FriocourtJamel Chelly
Mar 8, 2006·The European Journal of Neuroscience·Zoltán Molnár, André M Goffinet
Mar 8, 2006·The European Journal of Neuroscience·Zoltán MolnárHenry Kennedy
Jan 19, 2007·Journal of Anatomy·Jason NealVolney L Sheen
Feb 15, 2013·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Atsuo Fukuda, Tianying Wang
Jul 28, 2010·Brain Research·Geert J SchenkErno Vreugdenhil
Sep 26, 2006·Brain & Development·Kinuko Suzuki
Aug 25, 2015·Neurobiology of Disease·Melissa A StoufferFiona Francis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.